Back to Search
Start Over
Pomegranate Juice and Peel Extracts are Able to Inhibit Proliferation, Migration and Colony Formation of Prostate Cancer Cell Lines and Modulate the Akt/mTOR/S6K Signaling Pathway
- Source :
- Plant Foods for Human Nutrition. 75:54-62
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Pomegranate (Punica granatum) is known to contain polyphenols with many potential health benefits, including anti-tumoral, anti-inflammatory, and anti-microbial properties. It has been used in popular medicine for cancer treatment, which still represents the major cause of cancer-related deaths in men worldwide. Importantly, pomegranate peels are valuable by-products of the food industry that are rich in polyphenols. Here we report a comparison between juice and peel aqueous extracts in prostate cancer DU-145 and PC-3 cell lines. Both extracts were able to inhibit the proliferation, migration and colony formation of those cells, although peel extracts presented more robust effects compared to juice. Besides, the growth-related mTOR/S6K signaling pathway presented strong inhibition after pomegranate extracts treatment. This study presents evidence that both juice and isolated peel extracts from promegate fruit have important anti-cancer effects against prostate cancer cells, modulating the mTOR/S6K signaling pathway.
- Subjects :
- Male
0301 basic medicine
Cell signaling
P70-S6 Kinase 1
Pharmacology
Pomegranate
Cell Line
03 medical and health sciences
Prostate cancer
chemistry.chemical_compound
0404 agricultural biotechnology
medicine
Humans
Protein kinase B
PI3K/AKT/mTOR pathway
Cell Proliferation
030109 nutrition & dietetics
biology
Plant Extracts
TOR Serine-Threonine Kinases
Prostatic Neoplasms
04 agricultural and veterinary sciences
medicine.disease
biology.organism_classification
040401 food science
chemistry
Chemistry (miscellaneous)
Polyphenol
Fruit
Punica
Proto-Oncogene Proteins c-akt
Signal Transduction
Food Science
Ellagic acid
Subjects
Details
- ISSN :
- 15739104 and 09219668
- Volume :
- 75
- Database :
- OpenAIRE
- Journal :
- Plant Foods for Human Nutrition
- Accession number :
- edsair.doi.dedup.....ff9e7aa03c49c4fff4cd4051a8d66145