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Of Lymph Nodes and CLL Cells: Deciphering the Role of CCR7 in the Pathogenesis of CLL and Understanding Its Potential as Therapeutic Target
- Source :
- Frontiers in Immunology, Frontiers in Immunology, Vol 12 (2021)
- Publication Year :
- 2021
- Publisher :
- Frontiers Media SA, 2021.
-
Abstract
- The lymph node (LN) is an essential tissue for achieving effective immune responses but it is also critical in the pathogenesis of chronic lymphocytic leukemia (CLL). Within the multitude of signaling pathways aberrantly regulated in CLL the homeostatic axis composed by the chemokine receptor CCR7 and its ligands is the main driver for directing immune cells to home into the LN. In this literature review, we address the roles of CCR7 in the pathophysiology of CLL, and how this chemokine receptor is of critical importance to develop more rational and effective therapies for this malignancy.
- Subjects :
- lcsh:Immunologic diseases. Allergy
Receptors, CCR7
CLL (chronic lymphocytic leukemia)
medicine.medical_treatment
Chronic lymphocytic leukemia
Immunology
Gene Expression
chemical and pharmacologic phenomena
C-C chemokine receptor type 7
Review
Ligands
Pathogenesis
Chemokine receptor
Immune system
immune system diseases
hemic and lymphatic diseases
Biomarkers, Tumor
Immune Tolerance
Tumor Microenvironment
Animals
Humans
Immunology and Allergy
Medicine
Molecular Targeted Therapy
Lymph node
pathophysiology
B-Lymphocytes
business.industry
Chemotaxis
Immunotherapy
lymph node
medicine.disease
Leukemia, Lymphocytic, Chronic, B-Cell
medicine.anatomical_structure
Cancer research
immunotherapy
Disease Susceptibility
Lymph Nodes
Signal transduction
lcsh:RC581-607
business
CCR7
Protein Binding
Subjects
Details
- ISSN :
- 16643224
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Frontiers in Immunology
- Accession number :
- edsair.doi.dedup.....ff9a0dc4f299d3c4f36281360fdcd32a