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Effect of inhaled acetone concentrations on exhaled breath acetone concentrations at rest and during exercise
- Source :
- Journal of Breath Research
- Publication Year :
- 2020
-
Abstract
- Real-time measurements of the differences in inhaled and exhaled, unlabeled and fully deuterated acetone concentration levels, at rest and during exercise, have been conducted using proton transfer reaction mass spectrometry. A novel approach to continuously differentiate between the inhaled and exhaled breath acetone concentration signals is used. This leads to unprecedented fine grained data of inhaled and exhaled concentrations. The experimental results obtained are compared with those predicted using a simple three compartment model that theoretically describes the influence of inhaled concentrations on exhaled breath concentrations for volatile organic compounds with high blood:air partition coefficients, and hence is appropriate for acetone. An agreement between the predicted and observed concentrations is obtained. Our results highlight that the influence of the upper airways cannot be neglected for volatiles with high blood:air partition coefficients, i.e. highly water soluble volatiles.
- Subjects :
- Pulmonary and Respiratory Medicine
Inhalation Exposure
Volatile Organic Compounds
Chromatography
Time Factors
Rest
010401 analytical chemistry
Exhalation
Deuterated acetone
01 natural sciences
0104 chemical sciences
Partition coefficient
Acetone
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Water soluble
030228 respiratory system
chemistry
Breath Tests
Humans
Exercise
Proton-transfer-reaction mass spectrometry
Subjects
Details
- ISSN :
- 17527155
- Database :
- OpenAIRE
- Journal :
- Journal of Breath Research
- Accession number :
- edsair.doi.dedup.....ff985ac6d6644617fce538d4166a3304
- Full Text :
- https://doi.org/10.1088/1752-7163/ab613a