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Synthesis and Characterization of Drug-Loaded Poly(ε-caprolactone)/Silica Hybrid Nanofibrous Scaffolds
- Source :
- Journal of Nanomaterials, Vol 2013 (2013)
- Publication Year :
- 2013
- Publisher :
- Hindawi Publishing Corporation, 2013.
-
Abstract
- We produced drug-loaded poly(ε-caprolactone) (PCL)/silica hybrid nanofibrous scaffolds with various silica sol contents (0 vol%, 10 vol%, 15 vol%, and 20 vol%) using electrospinning and examined their physicochemical properties, mechanical properties, drug release behavior, andin vitrobiocompatibility to evaluate their potential application for guided bone regeneration (GBR). The loading efficiency of tetracycline hydrochloride (TCH) drug was remarkably enhanced by hybridizing the PCL solution with the silica sol. All produced hybrid scaffolds had a highly nanofibrous structure, in which the silica phase was homogeneously hybridized with the PCL polymer, while preserving their intrinsic characteristics. This led to considerable increases in hydrophilicity and mechanical properties (e.g., ultimate tensile strength and elastic modulus). In addition, the release rate and cumulative maximum amounts of the TCH from the hybrid scaffolds significantly increased with increasing the silica content, while all produced hybrid nanofibrous scaffolds showed good biocompatibility assessed byin vitrocell tests.
- Subjects :
- chemistry.chemical_classification
Materials science
Biocompatibility
Article Subject
Polymer
Electrospinning
Tetracycline Hydrochloride
chemistry.chemical_compound
chemistry
Chemical engineering
lcsh:Technology (General)
Ultimate tensile strength
lcsh:T1-995
General Materials Science
Composite material
Bone regeneration
Caprolactone
Elastic modulus
Subjects
Details
- Language :
- English
- ISSN :
- 16874110
- Database :
- OpenAIRE
- Journal :
- Journal of Nanomaterials
- Accession number :
- edsair.doi.dedup.....ff8eb06c3d44821829129c56805848f8
- Full Text :
- https://doi.org/10.1155/2013/351810