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Pustular drug eruption due to Panax notoginseng saponins
- Source :
- Drug Design, Development and Therapy
- Publication Year :
- 2014
- Publisher :
- Dove Medical Press, 2014.
-
Abstract
- ZhiQiang Yin,1,* LiWen Ma,1,* JiaLi Xu,2,* JiPing Xia,1 Dan Luo1 1Department of Dermatology, 2Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Jiangsu, People's Republic of China*These authors contributed equally to this work Abstract: Panax notoginseng saponins (PNS) are a patented product in the People's Republic of China, and have extensive effects on the cardiovascular system. Here we report on four elderly patients (one male and three female) with drug eruption induced by PNS injection. All developed a sudden skin rash with pruritus from head to foot, and subsequently accepted hospitalization. In each case, PNS had been used for less than 1 week before appearance of the rash. No specific short-term medications or changes in diet or exposure to environmental factors immediately prior to appearance of the rash were identified. These four patients had some interesting features in common, ie, pustules, fever, and elevated circulating neutrophil counts, which required high-dose, long-term glucocorticoid therapy. To our knowledge, this is the first report of pustular drug eruption induced by PNS and provides a useful reference and warning for clinicians. Keywords: pustule, drug eruption, acute generalized exanthematous pustulosis, Panax notoginseng saponins
- Subjects :
- Male
medicine.medical_specialty
Pharmaceutical Science
Panax notoginseng
Pharmacology
acute generalized exanthematous pustulosis
Drug Discovery
Medicine
Humans
Case Series
Glucocorticoids
Aged
Aged, 80 and over
pustule
Drug Design, Development and Therapy
biology
business.industry
Middle Aged
Saponins
medicine.disease
biology.organism_classification
Acute generalized exanthematous pustulosis
Rash
Dermatology
Panax notoginseng saponins
Drug eruption
Hospitalization
Glucocorticoid therapy
Female
Drug Eruptions
medicine.symptom
business
drug eruption
Drugs, Chinese Herbal
Subjects
Details
- Language :
- English
- ISSN :
- 11778881
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Drug Design, Development and Therapy
- Accession number :
- edsair.doi.dedup.....ff7fde3f9aefb2afa7e6ee3269198bbd