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Reactive oxygen species of neutrophils from patients with monosomy 7 in the bone marrow: Contradictory chemiluminescence activity by whole blood or by purified cells
- Source :
- Europe PubMed Central
- Publication Year :
- 2009
- Publisher :
- Wiley, 2009.
-
Abstract
- Monosomy 7, a deletion of the long arm of chromosome 7, was shown in the neutrophils of peripheral blood in 5 of 6 patients with a myelodysplastic syndrome or leukemia who had monosomy 7 in their bone marrow cells. In a chemiluminescence assay the production of reactive oxygen species by neutrophils from patients was increased in whole blood and decreased in purified cells, which suggests that neutrophils with monosomy 7 tolerate poorly the cell purification procedures used. The in vitro migration of purified neutrophils obtained from patients with monosomy 7 was impaired. It is known that patients with monosomy 7 have an increased susceptibility to infections. It is possible that neutrophils with monosomy 7 are too easily triggered to a full-scale respiratory burst and thereby the cells exhaust their ability to eliminate invading microbes efficiently.
- Subjects :
- Adult
Male
Monosomy
Neutrophils
Chromosome Disorders
Granulocyte
Biology
Leukocyte Count
03 medical and health sciences
0302 clinical medicine
medicine
Humans
Aged
Whole blood
Chromosome Aberrations
chemistry.chemical_classification
Reactive oxygen species
Hematology
General Medicine
Middle Aged
Aneuploidy
medicine.disease
Molecular biology
In vitro
3. Good health
Respiratory burst
Chemotaxis, Leukocyte
Leukemia
medicine.anatomical_structure
chemistry
030220 oncology & carcinogenesis
Luminescent Measurements
Immunology
Female
Bone marrow
Reactive Oxygen Species
Chromosomes, Human, Pair 7
030215 immunology
Subjects
Details
- ISSN :
- 16000609 and 09024441
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- European Journal of Haematology
- Accession number :
- edsair.doi.dedup.....ff6f9b52595ff65e1b781fba724b288a