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The Bioassay-Guided Isolation of Growth Inhibitors of Adult T-Cell Leukemia (ATL), from the Jamaican Plant Hyptis verticillata, and NMR Characterization of Hyptoside
- Source :
- Molecules; Volume 17; Issue 8; Pages: 9931-9938, Molecules
- Publication Year :
- 2012
- Publisher :
- Molecular Diversity Preservation International, 2012.
-
Abstract
- Through bioassay-guided isolation, five compounds with growth inhibitory activity on S1T, an adult T-cell leukemia (ATL) cell line, were isolated from the crude methanol extract of the aerial parts of Hyptis verticillata.
- Subjects :
- lignan
ATL
bioassay-guided isolation
S1T
growth inhibitor
NMR
structure
T-cell leukemia
Pharmaceutical Science
Antineoplastic Agents
Apoptosis
Growth inhibitory
Biology
Article
Analytical Chemistry
Inhibitory Concentration 50
chemistry.chemical_compound
Cell Line, Tumor
hemic and lymphatic diseases
Drug Discovery
medicine
Humans
Leukemia-Lymphoma, Adult T-Cell
Bioassay
Hyptis verticillata
Physical and Theoretical Chemistry
Nuclear Magnetic Resonance, Biomolecular
Lignan
Traditional medicine
Plant Extracts
Organic Chemistry
Plant Components, Aerial
Isolation (microbiology)
medicine.disease
Growth Inhibitors
Leukemia
chemistry
Biochemistry
Chemistry (miscellaneous)
Cell culture
Molecular Medicine
Hyptis
Drug Screening Assays, Antitumor
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Database :
- OpenAIRE
- Journal :
- Molecules; Volume 17; Issue 8; Pages: 9931-9938
- Accession number :
- edsair.doi.dedup.....ff5222572b15eec01ca7abed50fddaaa
- Full Text :
- https://doi.org/10.3390/molecules17089931