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Efficient Photodynamic Therapy of Prostate Cancer Cells through an Improved Targeting of the Cation-Independent Mannose 6-Phosphate Receptor
- Source :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, MDPI, 2019, 20 (11), pp.2809. ⟨10.3390/ijms20112809⟩, International Journal of Molecular Sciences, Vol 20, Iss 11, p 2809 (2019)
- Publication Year :
- 2019
- Publisher :
- HAL CCSD, 2019.
-
Abstract
- This article belongs to the Special Issue Insights into Photodynamic TherapyThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).; International audience; The aim of the present work is the development of highly efficient targeting molecules to specifically address mesoporous silica nanoparticles (MSNs) designed for the photodynamic therapy (PDT) of prostate cancer. We chose the strategy to develop a novel compound that allows the improvement of the targeting of the cation-independent mannose 6-phosphate receptor, which is overexpressed in prostate cancer. This original sugar, a dimannoside-carboxylate (M6C-Man) grafted on the surface of MSN for PDT applications, leads to a higher endocytosis and thus increases the efficacy of MSNs. View Full-TextKeywords: mannose 6-phosphate analogues; binding affinity; mesoporous silica nanoparticles; photodynamic therapy
- Subjects :
- Male
mannose 6-phosphate analogues
medicine.medical_treatment
Mannose
Photodynamic therapy
02 engineering and technology
010402 general chemistry
Endocytosis
01 natural sciences
Receptor, IGF Type 2
Catalysis
lcsh:Chemistry
Inorganic Chemistry
chemistry.chemical_compound
Prostate cancer
Cell Line, Tumor
binding affinity
medicine
Humans
[CHIM]Chemical Sciences
Physical and Theoretical Chemistry
Receptor
mesoporous silica nanoparticles
lcsh:QH301-705.5
Molecular Biology
Spectroscopy
Mannosephosphates
Communication
Organic Chemistry
Prostatic Neoplasms
General Medicine
Mesoporous silica
Silicon Dioxide
021001 nanoscience & nanotechnology
medicine.disease
0104 chemical sciences
Computer Science Applications
Cation-independent mannose-6 phosphate receptor
lcsh:Biology (General)
lcsh:QD1-999
Photochemotherapy
chemistry
photodynamic therapy
Cancer research
Nanoparticles
0210 nano-technology
Subjects
Details
- Language :
- English
- ISSN :
- 16616596 and 14220067
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, MDPI, 2019, 20 (11), pp.2809. ⟨10.3390/ijms20112809⟩, International Journal of Molecular Sciences, Vol 20, Iss 11, p 2809 (2019)
- Accession number :
- edsair.doi.dedup.....ff50c16bc953dfa6b2816730e26783bb