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Integrated genome-wide analysis of expression quantitative trait loci aids interpretation of genomic association studies
- Source :
- Genome Biology
- Publication Year :
- 2016
-
Abstract
- Background Identification of single nucleotide polymorphisms (SNPs) associated with gene expression levels, known as expression quantitative trait loci (eQTLs), may improve understanding of the functional role of phenotype-associated SNPs in genome-wide association studies (GWAS). The small sample sizes of some previous eQTL studies have limited their statistical power. We conducted an eQTL investigation of microarray-based gene and exon expression levels in whole blood in a cohort of 5257 individuals, exceeding the single cohort size of previous studies by more than a factor of 2. Results We detected over 19,000 independent lead cis-eQTLs and over 6000 independent lead trans-eQTLs, targeting over 10,000 gene targets (eGenes), with a false discovery rate (FDR)
- Subjects :
- 0301 basic medicine
Adult
Male
Quantitative Trait Loci
Gene Expression
Context (language use)
Genome-wide association study
Single-nucleotide polymorphism
Biology
Quantitative trait locus
Regulatory Sequences, Nucleic Acid
Web Browser
Polymorphism, Single Nucleotide
03 medical and health sciences
Gene Frequency
SNP
Cluster Analysis
Humans
Genetic Predisposition to Disease
Alleles
Genetic association
Aged
Genetics
Gene Expression Profiling
Research
Reproducibility of Results
Genomics
Middle Aged
3. Good health
Gene expression profiling
MicroRNAs
030104 developmental biology
Expression quantitative trait loci
Female
Genome-Wide Association Study
Subjects
Details
- ISSN :
- 1474760X
- Volume :
- 18
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Genome biology
- Accession number :
- edsair.doi.dedup.....ff4c3cb1edef0208a1b83c0ac407b0ac