Back to Search
Start Over
Combined adipose mesenchymal stromal cell advanced therapy resolved a recalcitrant leg ulcer in an 85-year-old patient
- Source :
- Regenerative medicine. 15(9)
- Publication Year :
- 2020
-
Abstract
- Venous leg ulcers (VLU) represent an uphill economic, health and social burden, aggravated in the elderly. Best-practice care interventions are often insufficient and alternative therapies need to be explored. Herein, we have treated for the first time a chronic VLU in an elderly patient by combining cell therapy and tissue engineering in the context of a compassionate use. The administration of allogeneic adipose-derived mesenchymal stromal cells (MSCs) embedded in a plasma-based bioengineered dermis covering the ulcer bed and also injected into the ulcer margins led to the complete closure of a 10-year recalcitrant VLU in an 85-year-old patient. Regenerative properties of MSCs might be boosted by the use of bioengineered matrices for their delivery.
- Subjects :
- Embryology
medicine.medical_specialty
Stromal cell
Biomedical Engineering
Adipose tissue
Context (language use)
Varicose Ulcer
Cell therapy
03 medical and health sciences
0302 clinical medicine
Dermis
Tissue engineering
medicine
Humans
030304 developmental biology
Aged
Aged, 80 and over
0303 health sciences
Tissue Engineering
business.industry
Mesenchymal stem cell
Leg Ulcer
Mesenchymal Stem Cells
Surgery
Leg ulcer
medicine.anatomical_structure
Adipose Tissue
030220 oncology & carcinogenesis
business
Subjects
Details
- ISSN :
- 1746076X
- Volume :
- 15
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Regenerative medicine
- Accession number :
- edsair.doi.dedup.....ff4c38bd22be9a00e48446ba2629d9d3