Back to Search Start Over

Anticardiolipin Antibodies in Patients with Cancer: A Case–Control Study

Authors :
Md. Ashraful Islam Nipu
Shoumik Kundu
Sayeda Sadia Alam
Ashrafun Naher Dina
Md. Ashraful Hasan
Mohammad Khan
Md. Ibrahim Khalil
Tareq Hossan
Md Asiful Islam
Source :
Cancers; Volume 15; Issue 7; Pages: 2087
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

Antiphospholipid antibodies are highly prevalent in autoimmune diseases and mainly associated with thromboembolic events, which is one of the major reasons for cancer-related mortality. Confirmed adult cancer patients were included (n = 40) with an equal number of age- and sex-matched healthy controls. The presence and concentration of anticardiolipin antibodies were investigated by the enzyme-linked immunosorbent assay using the venous blood samples. aCL antibodies were detected in 60.0% (n = 24) of the cancer patients compared to none in the healthy controls (p < 0.001). The serum concentration of aCL antibodies was significantly higher in cancer patients than controls (p < 0.001) and ranged from 89.0 U/mL to 133.0 U/mL among the aCL-positive patients. All the lung cancer patients (n = 6) were diagnosed with positive aCL, and a borderline significant association of aCL antibody positivity was observed in colon cancer patients (p = 0.051). About 72.7% of the advanced-stage cancer individuals and 81.8% of the cancer patients who underwent surgery were diagnosed with positive aCL antibodies. A significant association of aCL antibody positivity was observed with cancer patients comorbid with heart diseases (p = 0.005). The prevalence and serum levels of aCL antibodies were significantly higher in cancer patients compared to healthy controls. Cancer patients (i.e., lung, liver, and colon), at advanced-stage, comorbid with heart diseases, who underwent surgery, were more likely to be diagnosed with aCL antibodies.

Details

ISSN :
20726694
Volume :
15
Database :
OpenAIRE
Journal :
Cancers
Accession number :
edsair.doi.dedup.....ff2906f4e7b393df38c96d421244cc46
Full Text :
https://doi.org/10.3390/cancers15072087