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Organized screening detects breast cancer at earlier stage regardless of molecular phenotype
- Source :
- Journal of Cancer Research and Clinical Oncology. 144:1769-1775
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- Mortality reduction attributable to organized breast screening is modest. Screening may be less effective at detecting more aggressive cancers at an earlier stage. This study was conducted to determine the relative efficacy of screening mammography to detect cancers at an earlier stage by molecular phenotype. We identified 2882 women with primary invasive breast cancer diagnosed between January 1, 2008 and December 31, 2012 and who had a mammogram through the Ontario Breast Screening Program in the 28 months before diagnosis. Five tumor phenotypes were defined by expression of estrogen (ER) and progesterone (PR) receptors and HER2/neu oncogene. We conducted univariable and multivariable analyses to describe the predictors of detection as an interval cancer. Additional analyses identified predictors of detection at stages II, III, or IV compared with stage I, by phenotype. Analyses were adjusted for the effects of age, grade, and breast density. ER negative and HER2 positive tumors were over-represented among interval cancers, and triple negative cancers were more likely than ER +/HER2 − cancers to be detected as interval cancers OR 2.5 (95% CI 2.0–3.2, p
- Subjects :
- Oncology
Cancer Research
medicine.medical_specialty
Receptor, ErbB-2
medicine.drug_class
Population
Molecular phenotype
Breast Neoplasms
Triple Negative Breast Neoplasms
03 medical and health sciences
0302 clinical medicine
Breast cancer
Internal medicine
Biomarkers, Tumor
Humans
Medicine
030212 general & internal medicine
Stage (cooking)
skin and connective tissue diseases
education
Early Detection of Cancer
Neoplasm Staging
Cancer staging
education.field_of_study
Hematology
business.industry
General Medicine
Middle Aged
medicine.disease
Phenotype
Cross-Sectional Studies
Receptors, Estrogen
Estrogen
030220 oncology & carcinogenesis
Female
Receptors, Progesterone
business
Mammography
Subjects
Details
- ISSN :
- 14321335 and 01715216
- Volume :
- 144
- Database :
- OpenAIRE
- Journal :
- Journal of Cancer Research and Clinical Oncology
- Accession number :
- edsair.doi.dedup.....ff1c88c022ec3bd5919f43b5d2f32b70