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Increased antibody levels to stage-specific Epstein-Barr virus antigens in systemic autoimmune diseases reveal a common pathology
- Source :
- Scandinavian journal of clinical and laboratory investigation. 79(1-2)
- Publication Year :
- 2019
-
Abstract
- The immune responses to antigens from different stages of the Epstein-Barr virus (EBV) life cycle were investigated in systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjogren's syndrome (SS), and systemic sclerosis (SSc) to gain knowledge of EBV's involvement in the etiology of systemic autoimmune diseases (SADs) and for an overview of the humoral immune responses against EBV. Investigations were performed by the use of ELISA. IgM, IgA, and IgG antibody binding to 11 EBV antigens: EBNA1, EBNA2, BALF5, EAD, BALF2, EA/R, VCA p18, VCA p23, gB, gp350, and gp42 were examined in serum pools from SAD patients and healthy controls (HCs). Increased antibody levels against the 11 EBV antigens in the SAD pools were seen compared to the HC pool. Specifically, SLE was characterized by strongly increased IgA to EAD both compared to HCs and other SADs, and RA was characterized by increased IgM levels to several EBV antigens. The SADs may be partly distinguished by their differential immune responses to various antigens in the EBV life cycle. All together, these findings support an association between EBV infection and SADs.
- Subjects :
- Adult
Male
Epstein-Barr Virus Infections
Herpesvirus 4, Human
Increased IgM level
Clinical Biochemistry
medicine.disease_cause
Antibodies, Viral
behavioral disciplines and activities
Virus
Arthritis, Rheumatoid
03 medical and health sciences
0302 clinical medicine
Immune system
Antigen
hemic and lymphatic diseases
mental disorders
medicine
Humans
Lupus Erythematosus, Systemic
Antigens, Viral
Aged
030203 arthritis & rheumatology
Aged, 80 and over
Scleroderma, Systemic
business.industry
Case-control study
General Medicine
Middle Aged
medicine.disease
Epstein–Barr virus
Immunity, Humoral
Immunoglobulin A
Sjogren's Syndrome
Immunoglobulin M
Rheumatoid arthritis
Case-Control Studies
Immunoglobulin G
Immunology
Etiology
Female
business
030215 immunology
Subjects
Details
- ISSN :
- 15027686
- Volume :
- 79
- Issue :
- 1-2
- Database :
- OpenAIRE
- Journal :
- Scandinavian journal of clinical and laboratory investigation
- Accession number :
- edsair.doi.dedup.....ff1bf093073b1293c8119aaee531279a