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Evolution of thyroid hormone distributor proteins
- Source :
- Molecular and Cellular Endocrinology. 459:43-52
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Thyroid hormones (THs) are evolutionarily old hormones, having effects on metabolism in bacteria, invertebrates and vertebrates. THs bind specific distributor proteins (THDPs) to ensure their efficient distribution through the blood and cerebrospinal fluid in vertebrates. Albumin is a THDP in the blood of all studied species of vertebrates, so may be the original vertebrate THDP. However, albumin has weak affinity for THs. Transthyretin (TTR) has been identified in the blood across different lineages in adults vs juveniles. TTR has intermediate affinity for THs. Thyroxine-binding globulin has only been identified in mammals and has high affinity for THs. Of these THDPs, TTR is the only one known to be synthesised in the brain and is involved in moving THs from the blood into the cerebrospinal fluid. We analysed the rates of evolution of these three THDPs: TTR has been most highly conserved and albumin has had the highest rate of divergence.
- Subjects :
- Models, Molecular
0301 basic medicine
Thyroid Hormones
endocrine system
medicine.medical_specialty
Globulin
Thyroxine-Binding Globulin
Gene Expression
Plasma protein binding
Biochemistry
Protein Structure, Secondary
Evolution, Molecular
03 medical and health sciences
Thyroxine-binding globulin
Endocrinology
Albumins
Internal medicine
medicine
Animals
Humans
Prealbumin
Selection, Genetic
Molecular Biology
Conserved Sequence
Phylogeny
030102 biochemistry & molecular biology
biology
Thyroid
Albumin
nutritional and metabolic diseases
Protein Transport
Vitamin D binding
Transthyretin
030104 developmental biology
medicine.anatomical_structure
biology.protein
Protein Binding
Hormone
Subjects
Details
- ISSN :
- 03037207
- Volume :
- 459
- Database :
- OpenAIRE
- Journal :
- Molecular and Cellular Endocrinology
- Accession number :
- edsair.doi.dedup.....ff0ca40b86bb1a484fc05896e469b263