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Patients with autoimmune polyendocrine syndrome type 1 have an increased susceptibility to severe herpesvirus infections
- Source :
- Clinical Immunology (Orlando, Fla.)
- Publication Year :
- 2021
-
Abstract
- Almost all patients with autoimmune polyendocrine syndrome type 1 (APS-1) have neutralizing antibodies against type 1 interferons (IFN), important mediators of antiviral defense. Recently, neutralizing anti-IFN antibodies were shown to be a risk factor of severe COVID-19. Here we show in a cohort of 44 patients with APS-1 that higher titers of neutralizing anti-IFN alpha 4 antibodies are associated with a higher and earlier incidence of VZV reactivation (herpes zoster). The patients also present with uncommonly severe clinical sequelae of herpetic infections. APS-1 patients had decreased humoral immune responses to varicella zoster virus, but cellular responses were comparable to healthy controls. These results suggest that blocking the type I interferon pathway in patients with APS-1 patients leads to a clinically significant immune deficiency, and susceptibility to herpesviruses should be taken into account when treating patients with APS-1.
- Subjects :
- Male
Herpesvirus 3, Human
Herpes zoster
CHRONIC MUCOCUTANEOUS CANDIDIASIS
medicine.disease_cause
Cohort Studies
APS-1, autoimmune polyendocrine syndrome type 1
Varicella zoster
0302 clinical medicine
Autoantibody
Interferon
Risk Factors
Immunology and Allergy
Medicine
Chronic mucocutaneous candidiasis
Child
Polyendocrinopathies, Autoimmune
Immunodeficiency
0303 health sciences
Immunity, Cellular
biology
Middle Aged
3. Good health
030220 oncology & carcinogenesis
Female
Antibody
medicine.drug
Adult
Herpes simplex
Adolescent
Immunology
VZV, varicella zoster virus
03 medical and health sciences
Young Adult
Immune system
AIRE
Full Length Article
Humans
IFN, interferon
Type I interferon
030304 developmental biology
Aged
business.industry
Varicella zoster virus
Interferon-alpha
VARICELLA
medicine.disease
PREVENTION
Autoimmune polyendocrine syndrome type 1
Varicella Zoster Virus Infection
biology.protein
HSV, herpes simplex virus
AUTOANTIBODIES
3111 Biomedicine
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Clinical Immunology (Orlando, Fla.)
- Accession number :
- edsair.doi.dedup.....ff03828487759ffed1d4a83e19796b0f