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Genetic analysis of skull shape variation and morphological integration in the mouse using interspecific recombinant congenic strains between C57BL/6 and mice of the mus spretus species
- Source :
- Evolution-International Journal of Organic Evolution, Evolution-International Journal of Organic Evolution, Wiley, 2009, 63 (10), pp.2668-86. ⟨10.1111/j.1558-5646.2009.00737.x⟩, Evolution-International Journal of Organic Evolution, 2009, 63 (10), pp.2668-86. ⟨10.1111/j.1558-5646.2009.00737.x⟩
- Publication Year :
- 2009
- Publisher :
- HAL CCSD, 2009.
-
Abstract
- International audience; To assess the genetic basis of the skull shape variation and morphological integration in mice, we have used a tool based on the cross between the distantly related mouse species Mus spretus (SEG/Pas strain) and the laboratory strain C57BL/6 called interspecific recombinant congenic strains (IRCSs). The genome of each IRCS consists on average of 1.3% of SEG/Pas derived sequences, located on multiple chromosomes as small-sized, DNA segments. Quantitative trait loci (QTL) on the skull shape, separated into dorsal and ventral sides, were analyzed in 17 IRCSs by a Procrustes superimposition method using 3D landmarks. The shapes of 16 strains differed significantly from C57BL/6. Discrepancy in the QTLs effects was found between the dorsal side and the anterior region of the ventral side due to a differential effect of the SEG/Pas alleles on the skull shape. A comprehensive analysis of all allelic combinations of the BCG-66H strain showed strong epistatic interactions between SEG/Pas segment acting on both skull sides. Epistatic pleiotropy and covariation between sides were dependent in SEG/Pas alleles direction and contributed to the strong morphological integration between sides. Introduction of Mus spretus alleles in a C57BL/6 background induced strong morphological changes mostly in SEG/Pas alleles direction and provided evidence for high level of morphological integration.
- Subjects :
- 0106 biological sciences
epistasis
Mus spretus
Cephalometry
Congenic
Quantitative trait locus
010603 evolutionary biology
01 natural sciences
Genetic analysis
03 medical and health sciences
Mice
Pleiotropy
pleiotropy
Genetics
Animals
Allele
Ecology, Evolution, Behavior and Systematics
030304 developmental biology
Recombination, Genetic
0303 health sciences
[SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE]
biology
Strain (biology)
Skull
fluctuating asymmetry
biology.organism_classification
Mice, Inbred C57BL
Covariation between traits
quantitative trait loci
Epistasis
Hybridization, Genetic
Procrustes superimposition
General Agricultural and Biological Sciences
Subjects
Details
- Language :
- English
- ISSN :
- 00143820 and 15585646
- Database :
- OpenAIRE
- Journal :
- Evolution-International Journal of Organic Evolution, Evolution-International Journal of Organic Evolution, Wiley, 2009, 63 (10), pp.2668-86. ⟨10.1111/j.1558-5646.2009.00737.x⟩, Evolution-International Journal of Organic Evolution, 2009, 63 (10), pp.2668-86. ⟨10.1111/j.1558-5646.2009.00737.x⟩
- Accession number :
- edsair.doi.dedup.....fef7f4a6b2c791237da74cee2de3abb6