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CNR1, central cannabinoid receptor gene, associated with susceptibility to hebephrenic schizophrenia
- Source :
- Molecular psychiatry. 7(5)
- Publication Year :
- 2001
-
Abstract
- To examine the cannabinoid hypothesis for pathogenesis of schizophrenia, we examined two kinds of polymorphisms of the CNR1 gene, which encodes human CB1 receptor, a subclass of central cannabinoid receptors, in schizophrenics and age-matched controls in the Japanese population. Allelic and genotypic distributions of polymorphism 1359G/A at codon 453 in the coding region and AAT triplet repeats in the 3' flanking region in the Japanese population were quite different from those in Caucasians. Although the polymorphism 1359G/A was not associated with schizophrenia, the triplet repeat polymorphism of the CNR1 gene was significantly associated with schizophrenia, especially the hebephrenic subtype (P = 0.0028). Hebephrenic schizophrenia showed significantly increased rate of the 9 repeat allele (P = 0.032, OR = 2.30, 95% CI (1.91-2.69)), and decreased rate of the 17 repeat allele (P = 0.011, OR = 0.208, 95% CI (0.098-0.439)). The present findings indicated that certain alleles or genotypes of the CNR1 gene may confer a susceptibility of schizophrenia, especially of the hebephrenic type.
- Subjects :
- Adult
Male
Psychosis
Genotype
medicine.medical_treatment
Receptors, Drug
Biology
Polymorphism, Single Nucleotide
Genetic determinism
Cellular and Molecular Neuroscience
Asian People
Japan
Trinucleotide Repeats
Polymorphism (computer science)
Reference Values
medicine
Coding region
Humans
Genetic Predisposition to Disease
Allele
Codon
Receptors, Cannabinoid
Molecular Biology
DNA Primers
Genetics
Schizophrenia, Paranoid
Base Sequence
Schizophrenia, Disorganized
medicine.disease
Psychiatry and Mental health
Schizophrenia
Female
Cannabinoid
Subjects
Details
- ISSN :
- 13594184
- Volume :
- 7
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Molecular psychiatry
- Accession number :
- edsair.doi.dedup.....fef21a99d07153f1db6b031edafd1316