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Hypercalcitoninemia and thyroid nodules
- Source :
- Diagnostic Cytopathology. 42:970-973
- Publication Year :
- 2014
- Publisher :
- Wiley, 2014.
-
Abstract
- Medullary thyroid carcinoma (MTC) can assume various cytomorphological and architectural forms, mimicking other thyroid and extra-thyroid tumors and rendering the cytological and histological diagnosis challenging. Consequently, measurement of calcitonin (CT) levels is generally considered to be more accurate than cytology in diagnosing MTC. Here, we report on a patient with a multinodular goiter and significantly elevated basal CT levels; based on cytology examination and CT immunocytostains, neither MTC nor C-cell hyperplasia was detected upon final histopathological examination. CT testing has a high false-positive rate and low positive predictive value for detecting clinically relevant MTC. Judicious integration of cytological examination with immunocytochemical stains (when needed) may be useful for selecting the most appropriate therapy and avoiding overtreatment (i.e., central neck lymph node dissection in the present case). This case demonstrates that cytological examination with ancillary techniques is still valuable in patients with thyroid nodules and suspicious MTC.
- Subjects :
- Adult
Calcitonin
Image-Guided Biopsy
Thyroid nodules
Pathology
medicine.medical_specialty
Histology
endocrine system diseases
Medullary cavity
Biopsy, Fine-Needle
Thyroid Gland
Pathology and Forensic Medicine
Thyroid carcinoma
Cytology
Adenocarcinoma, Follicular
medicine
Humans
Thyroid Nodule
Lymph node
business.industry
Thyroid
General Medicine
medicine.disease
Dissection
medicine.anatomical_structure
Female
Radiology
business
Subjects
Details
- ISSN :
- 87551039
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- Diagnostic Cytopathology
- Accession number :
- edsair.doi.dedup.....feef145d0d7021c11372023c5305d8a7