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Exploring the effects of galacto-oligosaccharides on the gut microbiota of healthy adults receiving amoxicillin treatment
- Source :
- British Journal of Nutrition, 112(4), 536-546, British Journal of Nutrition 112 (2014) 4, British Journal of Nutrition, 4, 112, 536-546
- Publication Year :
- 2014
-
Abstract
- In the present double-blind, randomised, parallel intervention study, the effects of the intake of galacto-oligosaccharides (GOS) on the gut microbiota of twelve healthy adult subjects (aged 18–45 years with a normal BMI (18–25 kg/m2)) receiving amoxicillin (AMX) treatment were determined. All the subjects were treated with AMX (375 mg; three times per d) for 5 d and given either GOS (n 6) or placebo (maltodextrin, n 6) (2·5 g; three times per d) during and 7 d after AMX treatment. Faecal samples were collected twice before starting the treatment and on days 2, 5, 8, 12, 19 and 26. Due to AMX treatment, a decrease in the abundance of Bifidobacterium spp., an overgrowth of Enterobacteriaceae, and a disruption of the metabolic activity of the microbiota (increase in succinate, monosaccharide and oligosaccharide levels in the faecal samples) were observed in both groups (PPin vitro, namely that GOS intake supports the recovery of the beneficial bifidobacteria and, indirectly, the production of butyrate after AMX treatment.
- Subjects :
- Male
Intestinal microbiota
Unclassified drug
Antibiotics
Oligosaccharides
Monosaccharide
Biomedical Innovation
Medicine (miscellaneous)
Lower Gastrointestinal Tract
bifidobacteria
Galacto-oligosaccharides
Gut flora
Oligosaccharide
fluids and secretions
Life
Galactose oligosaccharide
Protein analysis
Food science
Intestinal Mucosa
fermentation
Sensory Science and Eating Behaviour
Bifidobacterium
Intestine flora
Nutrition and Dietetics
human intestinal microbiota
Food Chemistry
Monosaccharides
Feces analysis
antibiotic-treatment
Double blind procedure
Vivinal
Anti-Bacterial Agents
Normal human
Body mass
Human experiment
Randomized controlled trial
dietary modulation
impact
Female
Bedtime dosage
Healthy Living
Human
medicine.drug
Adult
Diarrhea
Adolescent
medicine.drug_class
Butyrate
Diet supplementation
Biology
Placebo
Treatment duration
Evening dosage
Microbiology
diversity
Human intervention studies
Succinic acid
Low drug dose
Young Adult
Double-Blind Method
Maltodextrin
Enterobacteriaceae
Gastrointestinal symptom
Levensmiddelenchemie
medicine
Humans
Feces
VLAG
Global Nutrition
Wereldvoeding
Microbial Viability
fecal microbiota
Dietary intake
Amoxicillin
Antibiotic therapy
biology.organism_classification
Microbial activity
MSB - Microbiology and Systems Biology
Sensoriek en eetgedrag
feces
Parallel design
Butyric Acid
ELSS - Earth, Life and Social Sciences
prebiotics
Controlled study
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 00071145
- Database :
- OpenAIRE
- Journal :
- British Journal of Nutrition, 112(4), 536-546, British Journal of Nutrition 112 (2014) 4, British Journal of Nutrition, 4, 112, 536-546
- Accession number :
- edsair.doi.dedup.....feebceef78fd3dc5ad857dc2e8f29333