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β-Amyloid peptide interactions with biomimetic membranes: A multiparametric characterization
- Source :
- International Journal of Biological Macromolecules, International Journal of Biological Macromolecules, 2021, 181, pp.769-777. ⟨10.1016/j.ijbiomac.2021.03.107⟩, International Journal of Biological Macromolecules, Elsevier, 2021, 181, pp.769-777. ⟨10.1016/j.ijbiomac.2021.03.107⟩
- Publication Year :
- 2021
- Publisher :
- HAL CCSD, 2021.
-
Abstract
- International audience; Alzheimer's disease is the most common form of senile dementia in the world, and amyloid β peptide1-42 (Aβ1-42) is one of its two principal biological hallmarks. While interactome concept was getting forward the scientific community, we proposed that the study of the molecular interactions of amyloid β peptide with the biological membranes will allow to highlight underlying mechanisms responsive of AD. We have developed two simple liposomal formulations (phosphatidylcholine, cholesterol, phosphatidylglycerol) mimicking neuronal cell membrane (composition, charge, curvature radius). Interactions with Aβ1-42 and mutant oG37C, a stable oligomeric form of the peptide, were characterized according to a simple multiparametric procedure based on ThT fluorescence, liposome leakage assay, ATR-FTIR spectroscopy. Kinetic aggregation, membrane damage and peptide conformation provided our first methodologic bases to develop an original model to describe interactions of Aβ peptide and lipids.
- Subjects :
- [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Peptide
02 engineering and technology
Biochemistry
Interactome
Fluorescence
Cell membrane
03 medical and health sciences
chemistry.chemical_compound
Biomimetic Materials
Structural Biology
Phosphatidylcholine
Spectroscopy, Fourier Transform Infrared
medicine
Molecular Biology
030304 developmental biology
chemistry.chemical_classification
0303 health sciences
Liposome
Amyloid beta-Peptides
Membranes
Chemistry
Membranes, Artificial
Biological membrane
General Medicine
Alzheimer's disease
Fluoresceins
021001 nanoscience & nanotechnology
3. Good health
Peptide Conformation
Kinetics
Membrane
medicine.anatomical_structure
Liposomes
Biophysics
0210 nano-technology
β-Amyloid
Subjects
Details
- Language :
- English
- ISSN :
- 01418130
- Database :
- OpenAIRE
- Journal :
- International Journal of Biological Macromolecules, International Journal of Biological Macromolecules, 2021, 181, pp.769-777. ⟨10.1016/j.ijbiomac.2021.03.107⟩, International Journal of Biological Macromolecules, Elsevier, 2021, 181, pp.769-777. ⟨10.1016/j.ijbiomac.2021.03.107⟩
- Accession number :
- edsair.doi.dedup.....fed7c8940e1fec2040d32caa8cea2a41