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Population Screening for Urine Antigens to Detect Asymptomatic Subarachnoid Neurocysticercosis: A Pilot Study in Northern Peru
- Source :
- Am J Trop Med Hyg
- Publication Year :
- 2020
- Publisher :
- American Society of Tropical Medicine and Hygiene, 2020.
-
Abstract
- Subarachnoid neurocysticercosis (SANCC) is a severe and progressive brain infection with Taenia solium. We performed a pilot study of noninvasive screening for SANCC in two endemic villages in northern Peru using a urine antigen screen followed by brain magnetic resonance imaging for participants with elevated levels of antigen. Among the 978 participants screened, we identified eight individuals with SANCC, many of whom were asymptomatic. This represents a minimum prevalence of 0.8% of SANCC, a level higher than expected based on prior studies, and a positive predictive value of 62% for our novel urine screening test. Future studies should confirm whether early detection and management improve clinical outcomes.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
030231 tropical medicine
Neurocysticercosis
Pilot Projects
Urine
Asymptomatic
Subarachnoid Space
Young Adult
03 medical and health sciences
0302 clinical medicine
Antigen
Virology
Internal medicine
Peru
Taenia solium
medicine
Urine Antigens
Animals
Humans
Young adult
Child
Aged
Taeniasis
Asymptomatic Diseases
Aged, 80 and over
medicine.diagnostic_test
business.industry
Brain
Magnetic resonance imaging
Articles
Middle Aged
Northern Peru
Asymptomatic Subarachnoid Neurocysticercosis
Magnetic Resonance Imaging
medicine.drug_formulation_ingredient
Infectious Diseases
Antigens, Helminth
Female
Parasitology
medicine.symptom
business
purl.org/pe-repo/ocde/ford#3.03.06 [https]
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Am J Trop Med Hyg
- Accession number :
- edsair.doi.dedup.....fec9b5f03a1a28c714fdd88a55603f36