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Dietary Fiber: An Opportunity for a Global Control of Hyperlipidemia
- Source :
- Oxidative Medicine and Cellular Longevity, Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
- Publication Year :
- 2021
-
Abstract
- Dietary fiber has a long history in the intervention study of hyperlipidemia. In this review, current understandings of structures, sources, and natures of various kinds of dietary fibers (DFs) were analyzed first. Available evidences for the use of different varieties of DFs in the lipid-lowering action both in vitro and in vivo were subsequently classified, including both soluble ones, such as glucans, pectins, and gums, and insoluble ones, including arabinooxylans and chitosans, in order to draw a primary conclusion of their dose and molecular weight relationship with lipid-lowering effect. Their potential mechanisms, especially the related molecular mechanism of protective action in the treatment and prevention of hyperlipidemia, were summarized at last. Five major mechanisms are believed to be responsible for the antihyperlipidemic benefits of DFs, including low levels of energy, bulking effect, viscosity, binding capacity, and fermentation thus ameliorating the symptoms of hyperlipidemia. From the molecular level, DFs could possibly affect the activities of HMG-CoA reductase, LDL receptors, CYP7A1, and MAPK signaling pathway as well as other lipid metabolism-related target genes. In summary, dietary fibers could be used as alternative supplements to exert certain lipid-lowering effects on humans. However, more clinical evidence is needed to strengthen this proposal and its fully underlying mechanism still requires more investigation.
- Subjects :
- 0301 basic medicine
Dietary Fiber
Aging
Hyperlipidemias
Review Article
Biology
Pharmacology
Cholesterol 7 alpha-hydroxylase
Biochemistry
Mapk signaling pathway
03 medical and health sciences
Molecular level
In vivo
Hyperlipidemia
medicine
Humans
030109 nutrition & dietetics
QH573-671
Mechanism (biology)
Cell Biology
General Medicine
medicine.disease
030104 developmental biology
LDL receptor
Dietary fiber
Cytology
Subjects
Details
- ISSN :
- 19420994
- Volume :
- 2021
- Database :
- OpenAIRE
- Journal :
- Oxidative medicine and cellular longevity
- Accession number :
- edsair.doi.dedup.....fec427ee5342b987b7ed423d854b0415