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Comparing abrocitinib and dupilumab in the treatment of atopic dermatitis: a plain language summary
- Source :
- Immunotherapy. 14(1)
- Publication Year :
- 2021
-
Abstract
- Atopic dermatitis (AD, also called atopic eczema) is a long-term skin disease that causes intensely itchy, red skin. Healthcare providers can prescribe medicated creams and ointments to reduce the signs and symptoms of AD. However, these treatments are not always enough to provide relief. A new medicine called abrocitinib, which is taken every day as a tablet, reduces part of the body’s immune response that happens in AD. The clinical study described in this plain language summary, called JADE COMPARE, investigated how well and how safely 16 weeks of treatment with abrocitinib worked in adults with AD compared to placebo (‘dummy treatment’) and a medicine that is already approved for AD, called dupilumab. The study showed that abrocitinib was better than placebo in improving the signs and symptoms of AD after 16 weeks. In addition, patients who were taking abrocitinib 200 mg for 2 weeks experienced greater relief from itch than patients who were taking abrocitinib 100 mg, placebo, or dupilumab. More people who took abrocitinib 200 mg reported side effects than those taking abrocitinib 100 mg, placebo, or dupilumab, but most of these side effects were mild or moderate. ClinicalTrials.gov NCT number: NCT03720470 .
- Subjects :
- Adult
medicine.medical_specialty
Immunology
Signs and symptoms
Disease
Placebo
Antibodies, Monoclonal, Humanized
Severity of Illness Index
Dermatitis, Atopic
Clinical study
Double-Blind Method
Immunology and Allergy
Medicine
Humans
Language
Sulfonamides
business.industry
Atopic dermatitis
medicine.disease
Dupilumab
Dermatology
Pyrimidines
Treatment Outcome
Oncology
business
Healthcare providers
Subjects
Details
- ISSN :
- 17507448 and 03720470
- Volume :
- 14
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Immunotherapy
- Accession number :
- edsair.doi.dedup.....feb04d14d0ec88f45b5ea4b8e08a8206