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Motility Control of Bacteria-Actuated Biodegradable Polymeric Microstructures by Selective Adhesion Methods
- Source :
- Micromachines, Vol 5, Iss 4, Pp 1287-1295 (2014), Micromachines, Volume 5, Issue 4, Pages 1287-1295
- Publication Year :
- 2014
- Publisher :
- MDPI AG, 2014.
-
Abstract
- Certain bacteria have motility and can be made non-toxic, and using them for drug delivery has been proposed. For example, using bacteria with flagella motion in multiple spin actuators in drug delivery microrobots has been suggested. This paper investigates various adhesion enhancement methods for attaching bacteria on preferred surfaces of cubic polymeric microstructures to achieve the directional control of motion. Serratia marcescens which has an excellent swimming behavior and 50-μm sized cubic structures made of biodegradable poly-capro-lactone (PCL) are used. Three treatment methods are investigated and compared to the untreated control case. The first method is retarding bacterial attachments by coating certain surfaces with bovine serum albumin (BSA) which makes those surfaces anti-adherent to bacteria. The second and third methods are roughening the surfaces with X-ray irradiation and plasma respectively to purposely increase bacterial attachments on the roughened surfaces. The measured motilities of bacteria-tethered PCL microactuators are 1.40 μm/s for the BSA coating method, 0.82 μm/s for the X-ray irradiation, and 3.89 μm/s for the plasma treatment method. Therefore, among the methods investigated in the paper the plasma treatment method achieves the highest directionality control of bacteria motility.
- Subjects :
- Materials science
lcsh:Mechanical engineering and machinery
Motility
Nanotechnology
engineering.material
targeted drug delivery
Coating
lcsh:TJ1-1570
Electrical and Electronic Engineering
Bovine serum albumin
bacteria
Serratia marcescens
biology
Mechanical Engineering
biodegradable polymer
Adhesion
BSA coating
X-ray irradiation
biology.organism_classification
Biodegradable polymer
selective bacterial attachment
Targeted drug delivery
plasma treatment
Control and Systems Engineering
microactuators
bacteria-tethering
Drug delivery
biology.protein
engineering
Bacteria
microrobot
Biomedical engineering
Subjects
Details
- Language :
- English
- Volume :
- 5
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Micromachines
- Accession number :
- edsair.doi.dedup.....fea43862db4fb5c4539f8518f8ce2be8