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Genetic predisposition to acute respiratory distress syndrome in patients with severe sepsis
- Publication Year :
- 2013
-
Abstract
- OBJECTIVE: The objective of this study was to analyze the association between candidate gene polymorphisms and susceptibility to acute respiratory distress syndrome (ARDS) in patients with severe sepsis. METHODS: Patients older than 18 years admitted to the intensive care unit (ICU) with the diagnosis of severe sepsis were prospectively included. A blood sample was drawn on the first day of ICU admission, and DNA was extracted. We genotyped the insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE) gene (polymerase chain reaction) and the following single-nucleotide polymorphisms (TaqMan SNP genotyping assay): tumor necrosis factor α -376 G/A, -308 G/A, and -238 G/A; interleukin 8 -251 T/A; pre-B cell colony-enhancing factor -1001 G/T; and vascular endothelial growth factor +405 C/G and +936 C/T. Polymorphisms were selected based on reports on their association with ARDS. Variables associated in univariate analysis (P < 0.1) with the diagnosis of ARDS were included in a multiple logistic regression analysis. RESULTS: We studied 149 patients, of whom 35 presented ARDS. Variables included in the maximal multivariate model were male sex, chronic alcoholism, use of ACE inhibitors or angiotensin-receptor blockers, Simplified Acute Physiology Score II score, serum glucose concentration at ICU admission, and the presence of the allele D of the ACE gene. After adjustment for those variables, the presence of the allele D of the ACE gene (odds ratio, 4.75; 95% confidence interval, 1.02-22.20; P = 0.048) was significantly associated with the diagnosis of ARDS. CONCLUSION: The presence of the allele D of the ACE gene is associated with ARDS in patients with severe sepsis. 2.732 JCR (2013) Q2, 11/27 Critical care medicine, 27/68 Hematology
- Subjects :
- Adult
Male
ARDS
medicine.medical_specialty
Candidate gene
Genética humana
Critical Care and Intensive Care Medicine
Polymorphism, Single Nucleotide
Gastroenterology
law.invention
Young Adult
Gene Frequency
law
Sepsis
Internal medicine
Renin
Genetic predisposition
Humans
Medicine
Genetic Predisposition to Disease
Prospective Studies
Simplified Acute Physiology Score
Allele frequency
Aged
Respiratory Distress Syndrome
Univariate analysis
Polymorphism, Genetic
business.industry
Odds ratio
Middle Aged
medicine.disease
Intensive care unit
Intensive Care Units
Immunology
Emergency Medicine
Female
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....fea1e66cea9dd5579fc8dbfe5d582aea