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Novel Natural Products for Healthy Ageing from the Mediterranean Diet and Food Plants of Other Global Sources—The MediHealth Project
- Source :
- Molecules, 23 (5), Molecules, Vol. 23, No 5 (2018), Molecules: a journal of synthetic chemistry and natural product chemistry, Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
- Publication Year :
- 2018
- Publisher :
- MDPI, 2018.
-
Abstract
- There is a rapid increase in the percentage of elderly people in Europe. Consequently, the prevalence of age-related diseases will also significantly increase. Therefore, the main goal of MediHealth, an international research project, is to introduce a novel approach for the discovery of active agents of food plants from the Mediterranean diet and other global sources that promote healthy ageing. To achieve this goal, a series of plants from the Mediterranean diet and food plants from other origins are carefully selected and subjected to in silico, cell-based, in vivo (fly and mouse models), and metabolism analyses. Advanced analytical techniques complement the bio-evaluation process for the efficient isolation and identification of the bioactive plant constituents. Furthermore, pharmacological profiling of bioactive natural products, as well as the identification and synthesis of their metabolites, is carried out. Finally, optimization studies are performed in order to proceed to the development of innovative nutraceuticals, dietary supplements or herbal medicinal products. The project is based on an exchange of researchers between nine universities and four companies from European and non-European countries, exploiting the existing complementary multidisciplinary expertise. Herein, the unique and novel approach of this interdisciplinary project is presented. ISSN:1420-3049
- Subjects :
- Mediterranean diet
Nutritional Sciences
natural products
International Cooperation
Phytochemicals
MediHealth
healthy ageing
food plants
metabolites
bioavailability
pharmacology
phytochemistry
synthetic chemistry
Pharmaceutical Science
Diet, Mediterranean
01 natural sciences
Analytical Chemistry
Healthy Aging
Mice
Drug Discovery
Elderly people
2. Zero hunger
International research
ddc:615
Pharmacology. Therapy
Concept Paper
3. Good health
Chemistry
Drosophila melanogaster
Chemistry (miscellaneous)
Molecular Medicine
Plants, Edible
Biological Availability
Biology
Nutraceutical
Animals
Humans
Physical and Theoretical Chemistry
Biological Products
Plants, Medicinal
010405 organic chemistry
business.industry
Organic Chemistry
0104 chemical sciences
Biotechnology
Mice, Inbred C57BL
010404 medicinal & biomolecular chemistry
Dietary Supplements
Interdisciplinary Communication
Healthy ageing
business
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Database :
- OpenAIRE
- Journal :
- Molecules, 23 (5), Molecules, Vol. 23, No 5 (2018), Molecules: a journal of synthetic chemistry and natural product chemistry, Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
- Accession number :
- edsair.doi.dedup.....fea18d04b6e62be01b0667169df155ba