Back to Search
Start Over
The Interleukin-33-p38 Kinase Axis Confers Memory T Helper 2 Cell Pathogenicity in the Airway
- Source :
- Immunity. (2):294-308
- Publisher :
- Elsevier Inc.
-
Abstract
- Memory CD4 + T helper (Th) cells provide long-term protection against pathogens and are essential for the development of vaccines; however, some antigen-specific memory Th cells also drive immune-related pathology, including asthma. The mechanisms regulating the pathogenicity of memory Th cells remain poorly understood. We found that interleukin-33 (IL-33)-ST2 signals selectively licensed memory Th2 cells to induce allergic airway inflammation via production of IL-5 and that the p38 MAP kinase pathway was a central downstream target of IL-33-ST2 in memory Th2 cells. In addition, we found that IL-33 induced upregulation of IL-5 by memory CD4 + Tcells isolated from nasal polyps of patients with eosinophilic chronic rhinosinusitis. Thus, IL-33-ST2-p38 signaling appears to directly instruct pathogenic memory Th2 cells to produce IL-5 and induce eosinophilic inflammation. Refereed/Peer-reviewed
- Subjects :
- MAPK/ERK pathway
p38 mitogen-activated protein kinases
Cell
Immunology
Receptors, Antigen, T-Cell
Biology
p38 Mitogen-Activated Protein Kinases
Mice
Nasal Polyps
Th2 Cells
Downregulation and upregulation
Eosinophilic
medicine
Immunology and Allergy
Animals
Humans
Nasal polyps
Pulmonary Eosinophilia
RNA, Small Interfering
Sinusitis
Cells, Cultured
Inflammation
Mice, Knockout
Mice, Inbred BALB C
immunologic memory
Interleukins
Receptors, Interleukin
asthma
medicine.disease
Interleukin-33
Interleukin-1 Receptor-Like 1 Protein
Asthma
Interleukin 33
Mice, Inbred C57BL
Th2 cells
medicine.anatomical_structure
Infectious Diseases
RNA Interference
Interleukin-5
Airway
Immunologic Memory
Subjects
Details
- Language :
- English
- ISSN :
- 10747613
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Immunity
- Accession number :
- edsair.doi.dedup.....fe99a093644cadeb35cc46e59788c9c8
- Full Text :
- https://doi.org/10.1016/j.immuni.2015.01.016