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Association of Megsin gene polymorphism with IgA nephropathy risk
- Source :
- Journal of receptor and signal transduction research. 35(2)
- Publication Year :
- 2014
-
Abstract
- This meta-analysis was conducted to assess the association of Megsin 2093C/T, 2180C/T, C25663G gene polymorphism with the risk of IgA nephropathy (IgAN). The association literatures were identified from PubMed, Embase, Cochrane Library and CBM-disc (China Biological Medicine Database) on 1 January 2014, and eligible reports were recruited and synthesized. Seven eligible reports were recruited into this meta-analysis for the association of Megsin 2093C/T, 2180C/T, C25663G gene polymorphism with IgAN risk. In this meta-analysis, the association of Megsin 2093C/T TT genotype with IgAN risk in Asians was found. Interestingly, Megsin C25663G G allele and GG genotype were associated with the risk of IgAN in Asian population. However, Megsin 2180C/T gene polymorphism was not associated with IgAN risk in Asians. In conclusion, Megsin 2093C/T TT genotype, and C25663G G allele and GG genotype were associated with the risk of IgAN in Asian population. However, more studies should be performed in the future to confirm this association.
- Subjects :
- Oncology
medicine.medical_specialty
Genotype
Cochrane Library
urologic and male genital diseases
Biochemistry
Polymorphism, Single Nucleotide
Nephropathy
Asian People
Internal medicine
medicine
Humans
Genetic Predisposition to Disease
Allele
Molecular Biology
Alleles
Genetic Association Studies
Serpins
Genetics
business.industry
Glomerulonephritis, IGA
Cell Biology
medicine.disease
Meta-analysis
Asian population
Gene polymorphism
business
Subjects
Details
- ISSN :
- 15324281
- Volume :
- 35
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of receptor and signal transduction research
- Accession number :
- edsair.doi.dedup.....fe921f2f978bb41ec04b93b390a72f43