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High density lipoprotein2. Relationship of the plasma levels of this lipoprotein species to its composition, to the magnitude of postprandial lipemia, and to the activities of lipoprotein lipase and hepatic lipase
High density lipoprotein2. Relationship of the plasma levels of this lipoprotein species to its composition, to the magnitude of postprandial lipemia, and to the activities of lipoprotein lipase and hepatic lipase
- Publication Year :
- 1987
-
Abstract
- Lipoprotein lipase (LPL) activity in postheparin plasma of 38 normolipidemic volunteers was related to the magnitude of postprandial lipemia after a fat meal, to triglyceride content of high density lipoprotein2 (HDL2), to hepatic lipase (HL) activity, and to HDL2 levels. LPL activity correlated indirectly with lipemia, triglyceride content of HDL2, HL activity, and levels of HDL2 but not of HDL3. HL activity correlated directly with lipemia and indirectly with HDL2 levels. Triglyceride content of HDL2 correlated directly with lipemia and indirectly with HDL2 levels. In HDL2, abundance of apolipoprotein (apo) A-II and the apoA-I/apoA-II ratio varied widely. The latter correlated positively with LPL activity and HDL2 levels, and, inversely, with HL activity, lipemia, and triglyceride content of HDL2. The study suggests that HDL-cholesterol is not an independent parameter of lipid transport, but is strongly affected by triglyceride metabolism through lipolytic enzymes, as exemplified by postprandial lipemia that affect both composition and plasma levels of HDL2.
- Subjects :
- medicine.medical_specialty
Apolipoprotein B
Triacylglycerol lipase
Coronary Disease
Apolipoproteins A
chemistry.chemical_compound
Eating
Internal medicine
medicine
Humans
Triglycerides
Lipoprotein lipase
biology
Cholesterol
digestive, oral, and skin physiology
Cholesterol, HDL
General Medicine
Lipoprotein Lipase
Endocrinology
Postprandial
chemistry
Liver
biology.protein
lipids (amino acids, peptides, and proteins)
Hepatic lipase
Cholesterol Esters
Lipoproteins, HDL
Lipoprotein
Research Article
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....fe920787d6059c413639b8575c7c98c7