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Biomolecular interaction and kinematics differences between P25 and E171 TiO2 nanoparticles
- Source :
- NanoImpact. 12:51-57
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Titanium dioxide (TiO2) nanoparticles (NPs) are used abundantly as food additives (E171). For the purpose of risk assessment, it is imperative to understand the behavior of these nanoparticles in a food relevant environment, and their consequent toxicology impacts. However, most of such studies use model TiO2 NPs (P25) as substitutes for E171. To understand the suitability of this approach, we investigated the functional behavior of E171 and P25 in solutions of bovine serum albumin (BSA) and sucrose as model food ingredients. Our data showed that E171 were better dispersed in BSA than P25. In sucrose, E171 displayed a reduction in agglomerated size while P25 agglomerated extensively. Adsorption studies showed that P25 attracted more pronounced corona formation per unit mass of material compared to E171. In vitro sedimentation, diffusion and dosimetry (ISDD) results demonstrated that the time-weighted dosage of E171 was more than two-folds higher than P25, implying that any test performed using P25 to model E171 would underestimate actual dosage and potential toxicity. Taken collectively, this study demonstrated the specificity of TiO2 nanoparticle interaction with food ingredients, and the importance of using food-grade E171 TiO2 for food-relevant toxicological assessments. Accepted version
- Subjects :
- food.ingredient
Materials Science (miscellaneous)
Nanoparticle
02 engineering and technology
010501 environmental sciences
01 natural sciences
chemistry.chemical_compound
food
Adsorption
Bovine serum albumin
Safety, Risk, Reliability and Quality
0105 earth and related environmental sciences
Titanium Dioxide
Materials [Engineering]
biology
Chemistry
Food additive
Tio2 nanoparticles
Public Health, Environmental and Occupational Health
021001 nanoscience & nanotechnology
female genital diseases and pregnancy complications
eye diseases
Unit mass
Chemical engineering
Titanium dioxide
biology.protein
Nanoparticles
0210 nano-technology
Safety Research
Potential toxicity
Subjects
Details
- ISSN :
- 24520748
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- NanoImpact
- Accession number :
- edsair.doi.dedup.....fe90e10a75a38eccab1643e70e16c54e