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Plasmapheresis for a Schizophrenic Patient with Drug-Induced Lupus Anti-Coagulant
- Source :
- Journal of International Medical Research. 24:147-150
- Publication Year :
- 1996
- Publisher :
- SAGE Publications, 1996.
-
Abstract
- A 59-year-old patient with schizophrenia developed Sjögren's syndrome. She also presented with the lupus anticoagulant attributed to long-term medication with chlorpromazine. Serial plasmapheresis treatments were performed to decrease the anti-coagulant activity. As a result, the activated partial thromboplastin time was temporarily improved, but the lupus anti-coagulant activity did not change. Because of her unstable emotional state, she continued to require chlorpromazine, but took a low dose of aspirin (87 mg/day) and never manifested any signs of thrombotic events. In view of the potential anti-thrombotic effects of chlorpromazine, it may not be necessary to use plasmapheresis in an attempt to reduce anti-coagulant activity among patients with chlorpromazine-induced lupus anti-coagulant.
- Subjects :
- medicine.medical_specialty
Chlorpromazine
medicine.medical_treatment
Biochemistry
Internal medicine
medicine
Humans
Antipsychotic
Lupus anticoagulant
Aspirin
Systemic lupus erythematosus
medicine.diagnostic_test
business.industry
Biochemistry (medical)
Thrombosis
Plasmapheresis
Cell Biology
General Medicine
Middle Aged
medicine.disease
Sjogren's Syndrome
Endocrinology
Schizophrenia
Lupus Coagulation Inhibitor
Anesthesia
Female
Partial Thromboplastin Time
business
Antipsychotic Agents
Partial thromboplastin time
medicine.drug
Subjects
Details
- ISSN :
- 14732300 and 03000605
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Journal of International Medical Research
- Accession number :
- edsair.doi.dedup.....fe869fa88e1728f482e2c4de8b28d3fb