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Amygdala activation and symptom dimensions in obsessive–compulsive disorder
- Source :
- British Journal of Psychiatry. 204:61-68
- Publication Year :
- 2014
- Publisher :
- Royal College of Psychiatrists, 2014.
-
Abstract
- BackgroundDespite knowledge of amygdala involvement in fear and anxiety, its contribution to the pathophysiology of obsessive–compulsive disorder (OCD) remains controversial. In the context of neuroimaging studies, it seems likely that the heterogeneity of the disorder might have contributed to a lack of consistent findings.AimsTo assess the influence of OCD symptom dimensions on amygdala responses to a well-validated emotional face-matching paradigm.MethodCross-sectional functional magnetic resonance imaging (fMRI) study of 67 patients with OCD and 67 age-, gender- and education-level matched healthy controls.ResultsThe severity of aggression/checking and sexual/religious symptom dimensions were significantly associated with heightened amygdala activation in those with OCD when responding to fearful faces, whereas no such correlations were seen for other symptom dimensions.ConclusionsAmygdala functional alterations in OCD appear to be specifically modulated by symptom dimensions whose origins may be more closely linked to putative amygdala-centric processes, such as abnormal fear processing.
- Subjects :
- Adult
Male
Obsessive-Compulsive Disorder
medicine.medical_specialty
Context (language use)
Anxiety
Severity of Illness Index
Amygdala
Phobic disorder
Young Adult
03 medical and health sciences
0302 clinical medicine
Neuroimaging
Interview, Psychological
Reaction Time
medicine
Humans
Psychiatry
Analysis of Variance
medicine.diagnostic_test
Aggression
Fear
Middle Aged
Magnetic Resonance Imaging
Disgust
030227 psychiatry
Psychiatry and Mental health
Cross-Sectional Studies
medicine.anatomical_structure
Case-Control Studies
Face
Regression Analysis
Female
medicine.symptom
Functional magnetic resonance imaging
Psychology
Photic Stimulation
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14721465 and 00071250
- Volume :
- 204
- Database :
- OpenAIRE
- Journal :
- British Journal of Psychiatry
- Accession number :
- edsair.doi.dedup.....fe7780719f6ac334678ed6bc46c7dcd3