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Patients with extraintestinal manifestations have a higher risk of developing pouchitis in ulcerative colitis: multivariate analysis
- Source :
- Scandinavian Journal of Gastroenterology. 38:1055-1058
- Publication Year :
- 2003
- Publisher :
- Informa UK Limited, 2003.
-
Abstract
- Restorative proctocolectomy and ileal pouch-anal anastomosis (IPAA) have been the surgical treatments of choice for ulcerative colitis (UC). However, the IPAA is sometimes complicated with pouchitis. Furthermore, the cumulative risk and risk factors for developing pouchitis in patients with UC undergoing IPAA have not been reported in any Asian population. The aim of our study is to clarify the cumulative risk and risk factors for developing pouchitis in Japanese patients with UC undergoing IPAA.Fifty-eight patients with UC undergoing IPAA were retrospectively evaluated for the presence of pouchitis, gender, age of onset, history of smoking, presence of extraintestinal manifestations (EIMs) and type of operation. The diagnosis of pouchitis was based on the pouchitis disease activity index. The cumulative risk and risk factors for developing pouchitis were assessed.The cumulative risks for developing pouchitis at 1 and 5 years were 9.0% and 14.4%, respectively. The estimated risks of pouchitis at 5 years was 48.1% in patients with EIMs and 4.6% in those without. Both univariate and multivariate analyses revealed that the presence of EIMs is a significant risk factor (hazard ratio 16.85, 95% confidence interval 3.12-91.00; P=0.001).The presence of EIMs is a significant risk factor for the development of pouchitis in Japanese patients with UC undergoing IPAA.
- Subjects :
- Male
medicine.medical_specialty
medicine.medical_treatment
Colonic Pouches
Pouchitis
Anastomosis
Gastroenterology
Postoperative Complications
Risk Factors
Internal medicine
medicine
Humans
Risk factor
business.industry
Proctocolectomy
Incidence (epidemiology)
medicine.disease
Ulcerative colitis
Multivariate Analysis
Colitis, Ulcerative
Female
Age of onset
Complication
business
Subjects
Details
- ISSN :
- 15027708 and 00365521
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Scandinavian Journal of Gastroenterology
- Accession number :
- edsair.doi.dedup.....fe6ff80d9a7c9ecad01b3983501be6b1