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Inhibition of the growth of human melanoma xenografts in nude mice by human tumor-specific cytotoxic T-cells
- Source :
- Journal of Surgical Oncology. 43:67-72
- Publication Year :
- 1990
- Publisher :
- Wiley, 1990.
-
Abstract
- Melanoma-specific T-cells (CTLs) are specifically cytotoxic for autologous tumor, when assayed in vitro. To examine their effectiveness in vivo, we tested the ability of these human T-cells to inhibit growth of human melanoma xenografts by using a Winn assay. Nude mice receiving specific CTLs (n = 10) demonstrated a dramatic inhibition of tumor growth. All treated mice were tumor-free at day 50 and nine remained tumor-free at day 65, vs. control mice (n = 10) with average tumor volumes of 321 mm3 and 808 mm3, respectively. To control for the possibility that a non-specific response to the human T-cells could inhibit tumor growth, an additional group received allospecific CTLs. There was no inhibition of tumor growth in this group (n = 8), with the average tumor volume of 2,768 mm3 at day 40 vs. 1,882 mm3 in the control group (n = 10). We conclude that these tumor-specific CTLs can inhibit tumor growth in vivo and may prove useful in the adoptive immunotherapy of melanoma.
- Subjects :
- Male
medicine.medical_treatment
Transplantation, Heterologous
Fluorescent Antibody Technique
Mice, Nude
Heterologous
Mice
In vivo
HLA-A2 Antigen
medicine
Animals
Humans
Cytotoxic T cell
Melanoma
Mice, Inbred BALB C
business.industry
General Medicine
Immunotherapy
medicine.disease
In vitro
Transplantation
Oncology
Immunology
Cancer research
Surgery
Human melanoma
business
Neoplasm Transplantation
T-Lymphocytes, Cytotoxic
Subjects
Details
- ISSN :
- 10969098 and 00224790
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Journal of Surgical Oncology
- Accession number :
- edsair.doi.dedup.....fe6f574d7dbb35464a117f4005e34e0e