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Hyperbaric oxygen preserves neurotrophic activity of carbon monoxide-exposed astrocytes
- Source :
- Toxicology Letters. 253:1-6
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- In astrocytes, carbon monoxide (CO) poisoning causes oxidative stress and mitochondrial dysfunction accompanied by caspase and calpain activation. Impairment in astrocyte function can be time-dependently reduced by hyperbaric (3bar) oxygen (HBO). Due to the central role of astrocytes in maintaining neuronal function by offering neurotrophic support we investigated the hypothesis that HBO therapy may exert beneficial effect on acute CO poisoning-induced impairment in intrinsic neurotrophic activity. Exposure to 3000ppm CO in air followed by 24-72h of normoxia caused a progressive decline of gene expression, synthesis and secretion of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) to different extent. 1h treatment with 100% oxygen disclosed a pressure- and time-dependent efficacy in preserving astrocytic neurotrophic support. The beneficial effect was most evident when the astrocytes were exposed to HBO 1-5h after exposure to CO. The results further support an active role of hyperbaric, not normobaric, oxygenation in reducing dysfunction of astrocytes after acute CO poisoning. By preserving endogenous neurotrophic activity HBO therapy might promote neuronal protection and thus prevent the occurrence of late neuropsychological sequelae.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Time Factors
Endogeny
Toxicology
medicine.disease_cause
03 medical and health sciences
0302 clinical medicine
Neurotrophin 3
Neurotrophic factors
Internal medicine
Nerve Growth Factor
medicine
Animals
Nerve Growth Factors
Rats, Wistar
Cells, Cultured
Caspase
Carbon Monoxide
Hyperbaric Oxygenation
Dose-Response Relationship, Drug
biology
Chemistry
Brain-Derived Neurotrophic Factor
Calpain
General Medicine
Oxygen
030104 developmental biology
Endocrinology
medicine.anatomical_structure
Nerve growth factor
Animals, Newborn
Gene Expression Regulation
Astrocytes
Anesthesia
biology.protein
030217 neurology & neurosurgery
Oxidative stress
Astrocyte
Neurotrophin
Subjects
Details
- ISSN :
- 03784274
- Volume :
- 253
- Database :
- OpenAIRE
- Journal :
- Toxicology Letters
- Accession number :
- edsair.doi.dedup.....fe6c0bcfd404e1e6e020512938b55866