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High-dose remifentanil prevents development of thermal hyperalgesia in a neuropathic pain model
- Source :
- British Journal of Anaesthesia. 110:287-292
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- Background Intraoperative nerve lesions can lead to chronic postoperative pain. There are conflicting data as to whether or not anaesthetics administered intraoperatively are beneficial. We investigated if remifentanil administered at the time of nerve injury was able to attenuate neuropathic hypersensitivity. Methods Rats were anaesthetized with isoflurane, endotracheally intubated, and a tail vein catheter was inserted. Rats received an i.v. infusion of either saline or low- or high-dose remifentanil (2 or 20 μg kg−1 min−1, respectively) for 20 min. During this time, rats received a spinal nerve L5 transection to induce neuropathic pain or a sham procedure. Behavioural tests to assess mechanical and cold allodynia and heat hyperalgesia were performed on postoperative days 1, 3, 7, 14, 21, and 28. Results Sham-operated animals exhibited no hypersensitivity regardless of the intraoperative remifentanil dose. In rats which received spinal nerve L5 transection, mechanical and cold allodynia developed with no significant differences between treatment groups. However, thermal hyperalgesia was reduced in rats given high-dose remifentanil: mean (standard deviation) area under the curve 426 (53) compared with 363 (34) and 342 (24) in saline or low-dose remifentanil treated rats, respectively (P Conclusions High-dose remifentanil administered at the time of transection of the spinal nerve at L5 prevents subsequent thermal hyperalgesia.
- Subjects :
- Male
Hot Temperature
Remifentanil
Rats, Sprague-Dawley
Piperidines
Physical Stimulation
Infusion Procedure
medicine
Animals
Pain, Postoperative
Behavior, Animal
business.industry
Nerve injury
Rats
Analgesics, Opioid
Cold Temperature
Spinal Nerves
Anesthesiology and Pain Medicine
Allodynia
Isoflurane
Hyperalgesia
Area Under Curve
Data Interpretation, Statistical
Spinal nerve
Anesthesia
Neuropathic pain
Neuralgia
medicine.symptom
business
medicine.drug
Subjects
Details
- ISSN :
- 00070912
- Volume :
- 110
- Database :
- OpenAIRE
- Journal :
- British Journal of Anaesthesia
- Accession number :
- edsair.doi.dedup.....fe645ee56ccd2278ffb6bb3a58788458