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Inverse Levels of Adiponectin in Type 1 and Type 2 Diabetes Are in Accordance with the State of Albuminuria
- Source :
- International Journal of Endocrinology, Vol 2015 (2015), International Journal of Endocrinology
- Publication Year :
- 2015
- Publisher :
- Hindawi Limited, 2015.
-
Abstract
- Aims.To investigate the behaviour of adiponectin (ApN) in patients with type 1 and type 2 diabetic nephropathy.Methods.ApN and inflammatory and other markers of the metabolic syndrome were compared across diabetes types, albumin excretion rate (AER), and creatinine clearance (CrCl) categories in 219 type 1 and type 2 diabetic patients.Results.Significant differences among ApN levels according to AER were found in both types of diabetes (F=8.45,df=2,P<0.001). With the progression of albuminuria, ApN increased in type 1 and decreased in type 2 diabetes. Patients with decreased CrCl had higher ApN levels than those with normal CrCl in either type of diabetes (F=12.7,df=1,P<0.001). The best model for ApN (R2=0.9002) obtained from stepwise regression in type 1 diabetes included CrCl, BMI, WBC, CRP, and age, while in type 2 diabetes (R2=0.2882) it included ppPG, LDL, and UA.Conclusion.ApN behaved differently in relation to albuminuria, increasing with its progression in type 1 diabetes and decreasing in type 2 diabetes. It was however increased in the subgroups with decreased CrCl in both types of diabetes. Albuminuria seems to be more important than renal insufficiency in the definition of ApN levels in type 1 and type 2 diabetes.
- Subjects :
- medicine.medical_specialty
animal structures
Article Subject
Endocrinology, Diabetes and Metabolism
Renal function
030209 endocrinology & metabolism
adiponectin
albuminuria
diabetes mellitus
Type 2 diabetes
030204 cardiovascular system & hematology
lcsh:Diseases of the endocrine glands. Clinical endocrinology
Diabetic nephropathy
03 medical and health sciences
0302 clinical medicine
Endocrinology
Diabetes mellitus
Internal medicine
medicine
Type 1 diabetes
lcsh:RC648-665
Adiponectin
Endocrine and Autonomic Systems
business.industry
medicine.disease
Albuminuria
Metabolic syndrome
medicine.symptom
business
hormones, hormone substitutes, and hormone antagonists
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 16878345 and 16878337
- Volume :
- 2015
- Database :
- OpenAIRE
- Journal :
- International Journal of Endocrinology
- Accession number :
- edsair.doi.dedup.....fe54676018ba73e28da736d712122381