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Antibacterial steroidal alkaloids from Holarrhena antidysenteriaca
- Source :
- Chinese Journal of Natural Medicines. 15:540-545
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Two new steroidal alkaloids, isoconkuressine and N-formylconessimine, together with 6 known steroidal alkaloids including conkuressine, conessine, isoconessimine, conimine, conarrhimine, and funtudienine, were isolated from the seeds of Holarrhena antidysenteriaca Wall.ex A.DC. Their intrinsic antibacterial activities and synergistic effects with penicillin and vancomycin were analyzed in methicillin sensitive staphylococcus aureus (MSSA) and methicillin resistant staphylococcus aureus (MRSA). Two of the steroidal alkaloids including one new compound (N-formylconessimine) showed potential antibacterial activity and possessed synergistic effects with penicillin and vancomycin, respectively.
- Subjects :
- Methicillin-Resistant Staphylococcus aureus
Staphylococcus aureus
030232 urology & nephrology
Microbial Sensitivity Tests
medicine.disease_cause
Microbiology
03 medical and health sciences
chemistry.chemical_compound
Alkaloids
0302 clinical medicine
Drug Discovery
medicine
Methicillin sensitive
Holarrhena
biology
Plant Extracts
General Medicine
biochemical phenomena, metabolism, and nutrition
biology.organism_classification
Methicillin-resistant Staphylococcus aureus
Anti-Bacterial Agents
Penicillin
Conessine
Complementary and alternative medicine
chemistry
030220 oncology & carcinogenesis
Vancomycin
Antibacterial activity
medicine.drug
Subjects
Details
- ISSN :
- 18755364
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Chinese Journal of Natural Medicines
- Accession number :
- edsair.doi.dedup.....fe540c78896aaf8e960fa24be4844871