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Innate and Adaptive Immune Response to Pneumonia Virus of Mice in a Resistant and a Susceptible Mouse Strain
- Source :
- Viruses, Vol 5, Iss 1, Pp 295-320 (2013), Viruses, Viruses; Volume 5; Issue 1; Pages: 295-320
- Publication Year :
- 2013
- Publisher :
- MDPI AG, 2013.
-
Abstract
- Respiratory syncytial virus (RSV) is the leading cause of infant bronchiolitis. The closely related pneumonia virus of mice (PVM) causes a similar immune-mediated disease in mice, which allows an analysis of host factors that lead to severe illness. This project was designed to compare the immune responses to lethal and sublethal doses of PVM strain 15 in Balb/c and C57Bl/6 mice. Balb/c mice responded to PVM infection with an earlier and stronger innate response that failed to control viral replication. Production of inflammatory cyto- and chemokines, as well as infiltration of neutrophils and IFN-γ secreting natural killer cells into the lungs, was more predominant in Balb/c mice. In contrast, C57Bl/6 mice were capable of suppressing both viral replication and innate inflammatory responses. After a sublethal infection, PVM-induced IFN-γ production by splenocytes was stronger early during infection and weaker at late time points in C57Bl/6 mice when compared to Balb/c mice. Furthermore, although the IgG levels were similar and the mucosal IgA titres lower, the virus neutralizing antibody titres were higher in C57Bl/6 mice than in Balb/c mice. Overall, the difference in susceptibility of these two strains appeared to be related not to an inherent T helper bias, but to the capacity of the C57Bl/6 mice to control both viral replication and the immune response elicited by PVM.
- Subjects :
- Chemokine
PVM
Balb/c and C57Bl/6 mice
innate and adaptive immunity
immunopathogenesis
lcsh:QR1-502
Adaptive Immunity
Virus
Article
lcsh:Microbiology
Rodent Diseases
03 medical and health sciences
Interferon-gamma
Mice
0302 clinical medicine
Immune system
Immunity
Virology
Animals
Humans
Pneumovirus Infections
Lung
030304 developmental biology
Disease Resistance
0303 health sciences
Mice, Inbred BALB C
Innate immune system
biology
Acquired immune system
Immunity, Innate
3. Good health
Killer Cells, Natural
Mice, Inbred C57BL
Infectious Diseases
Viral replication
Immunology
biology.protein
Murine pneumonia virus
Female
Chemokines
030215 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 19994915
- Volume :
- 5
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Viruses
- Accession number :
- edsair.doi.dedup.....fe4b8420a49e6a45ed1a9ee0549b24c5