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Erythrodermic Psoriasis Treated with Golimumab: A Case Report
- Source :
- Annals of Dermatology
- Publication Year :
- 2015
- Publisher :
- Korean Dermatological Association and The Korean Society for Investigative Dermatology, 2015.
-
Abstract
- Erythrodermic psoriasis (EP) is a very severe variant of psoriasis whose management poses a challenge to physicians, as currently available therapies often provide unsatisfactory results. Many biologics have been used to treat chronic plaque psoriasis, the most common form of psoriasis; however, their effectiveness for EP is poorly understood. A recently developed biologic, golimumab, has been extensively studied for the treatment of moderate-to-severe active rheumatoid arthritis, psoriatic arthritis, active ankylosing spondylitis, and chronic plaque psoriasis. However, no clinical trials have been performed for EP. Here, we report the case of a 32-year-old man who presented with severe psoriasis that previously failed to respond satisfactorily to methotrexate, cyclosporine, retinoid, narrow-band ultraviolet B phototherapy, and topical agents (i.e., steroids and calcipotriol). Skin lesions worsened progressively and developed into erythroderma. Psoriatic arthritis was also detected. Conventional therapies lacked efficacy. Therefore, we administered golimumab 50 mg. The skin lesions improved significantly according to the Psoriasis Area and Severity Index score after the first administration; lesions improved further throughout the treatment course. Although additional studies are required to fully evaluate the efficacy and safety of golimumab, this agent may be an alternative treatment strategy for some patients with recalcitrant EP.
- Subjects :
- medicine.medical_specialty
Ankylosing spondylitis
business.industry
Erythroderma
Case Report
Dermatology
medicine.disease
Golimumab
Erythrodermic psoriasis
Psoriatic arthritis
chemistry.chemical_compound
chemistry
Psoriasis Area and Severity Index
Psoriasis
Rheumatoid arthritis
medicine
Biological products
business
Calcipotriol
medicine.drug
Subjects
Details
- ISSN :
- 20053894 and 10139087
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Annals of Dermatology
- Accession number :
- edsair.doi.dedup.....fe3e184eec35df88d03bb6e9117b9f3b