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Plasma apelin level in acute myocardial infarction and its relation with prognosis: A prospective study
- Source :
- JRSM Cardiovascular Disease, Vol 10 (2021), JRSM Cardiovascular Disease
- Publication Year :
- 2021
- Publisher :
- SAGE Publications, 2021.
-
Abstract
- ObjectiveApelin is a novel adipocytokine with a significant role in ischemia/reperfusion injury that is synthesized and secreted in myocardial cells and coronary endothelium. There is debate on its value for the diagnosis and prognosis of myocardial infarction. We aimed to investigate plasma apelin level in patients with acute ST segment elevation (STEMI) and non-ST segment elevation (NSTEMI) myocardial infarction and its relationship with left ventricular function and prognostic parameters.MethodsForty-one patients with STEMI, 21 patients with NSTEMI and 10 patients as control group with normal coronary angiograms were included. Plasma apelin level at presentation was investigated regarding its relationship with other diagnostic and prognostic parameters.ResultsApelin level was significantly higher in acute myocardial infarction (0.31 ± 0.56 ng/mL) compared to control group (0.08 ± 0.05 ng/mL) (p 0.05). No correlation was found between apelin and NT-proBNP, hsCRP, troponin, ejection fraction (EF) and Killip score (p > 0.05). A positive correlation was found between apelin and TIMI, GRACE and Gensini scores (p ConclusionApelin level was found to be high in acute myocardial infarction. With its inotropic and vasodilator effects, apelin was thought to have a protective role against severe ischemia.
- Subjects :
- 0301 basic medicine
lcsh:Diseases of the circulatory (Cardiovascular) system
medicine.medical_specialty
Ischemia
030204 cardiovascular system & hematology
03 medical and health sciences
0302 clinical medicine
Internal medicine
Acute Myocardial Infarction
Medicine
cardiovascular diseases
Myocardial infarction
Prospective cohort study
business.industry
Coronary endothelium
General Medicine
Prognosis
medicine.disease
Apelin
030104 developmental biology
lcsh:RC666-701
Cardiology
business
Reperfusion injury
Research Article
Subjects
Details
- ISSN :
- 20480040
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- JRSM Cardiovascular Disease
- Accession number :
- edsair.doi.dedup.....fe3df9536f6126bf0111be3437010bbb