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Interactions of PIN and PGP auxin transport mechanisms

Authors :
Markus Geisler
Rodolphe Bouchard
Wendy Ann Peer
Angus S. Murphy
Joshua J. Blakeslee
Srinivas N. Makam
Jiří Friml
Ok Ran Lee
Jozef Mravec
Anindita Bandyopadhyay
Michael Sauer
Enrico Martinoia
Boosaree Titapiwatanakun
Source :
ResearcherID
Publication Year :
2007
Publisher :
Portland Press Ltd., 2007.

Abstract

Polarized transport of the plant hormone auxin influences multiple growth processes in plants and is regulated by plasma-membrane-localized efflux and uptake carriers. The PGP (P-glycoprotein) ABC transporters (ATP-binding-cassette transporters), PIN (pin-formed) subfamily of major facilitator proteins and members of AUX/LAX families have been shown to independently transport auxin both in planta and in heterologous systems. However, PIN- and PGP-mediated transport in heterologous systems exhibits decreased substrate specificity and inhibitor-sensitivity compared with what is seen in plants and plant cells. To determine whether PIN–PGP interactions enhance transport specificity, we analysed interactions of the representative auxin-transporting PGPs with PIN1 and AUX1 in planta and in heterologous systems. Here, we provide evidence that PINs and PGPs interact and function both independently and co-ordinately to control polar auxin transport and impart transport specificity and directionality. These interactions take place in protein complexes stabilized by PGPs in detergent-resistant microdomains.

Details

ISSN :
14708752 and 03005127
Volume :
35
Database :
OpenAIRE
Journal :
Biochemical Society Transactions
Accession number :
edsair.doi.dedup.....fe32c1f116abaaccc96766028b3ebbe5
Full Text :
https://doi.org/10.1042/bst0350137