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Induction of heat shock proteins prevents the arrhythmogenic substrate for atrial fibrillation
- Source :
- International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 25(8)
- Publication Year :
- 2009
-
Abstract
- Atrial fibrillation (AF) is the commonest arrhythmia. Studies have shown that atrial tachypacing (artificial persistent AF) causes electrical remodelling. This is characterised by the shortening of the atrial effective refractory period (ERP), in which reduction in L-type Ca(2+) channel current plays an essential part. Atrial fibrosis, a feature of structural remodelling, is induced by continuous infusion of angiotensin II, and has been associated with conduction delay in atria, which promotes AF. Acute atrial ischaemia, frequently observed during development of acute coronary syndrome, has been associated with atrial conduction heterogeneity, which also promotes AF. Induction of heat shock proteins (Hsp72 and Hsp27) by hyperthermia and/or geranylgeranylacetone has demonstrated to protect the heart against such atrial remodelling. The potent protective role of Hsp72 and Hsp27 against clinical AF in patients who underwent open heart surgery has been shown. Taken together, interventions that induce heat shock responses (including induction of Hsp72 and Hsp27) may prevent newly developed AF and delay the progression of paroxysmal AF to persistent AF.
- Subjects :
- Hyperthermia
Cancer Research
medicine.medical_specialty
Fever
Physiology
Ischemia
HSP27 Heat-Shock Proteins
HSP72 Heat-Shock Proteins
Dogs
Hsp27
Fibrosis
Physiology (medical)
Internal medicine
Heat shock protein
Atrial Fibrillation
Medicine
Animals
Humans
cardiovascular diseases
Heart Atria
biology
business.industry
Atrial fibrillation
medicine.disease
Angiotensin II
Shock (circulatory)
cardiovascular system
biology.protein
Cardiology
medicine.symptom
Diterpenes
business
Subjects
Details
- ISSN :
- 14645157
- Volume :
- 25
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
- Accession number :
- edsair.doi.dedup.....fe321d949609ccbb8d741ee6e2b52b10