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Utilization of silicon nanowire field-effect transistors for the detection of a cardiac biomarker, cardiac troponin I and their applications involving animal models
- Source :
- Scientific Reports, Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
- Publication Year :
- 2020
- Publisher :
- Nature Publishing Group UK, 2020.
-
Abstract
- This study develops an ultrasensitive electrical device, the silicon nanowire-field effect transistor (SiNW-FET) for detection of cardiac troponin I (cTnI) in obesity induced myocardial injury. The biosensor device utilizes metal–oxide–semiconductor (MOS) compatible top-down methodology for the fabrication process. After fabrication, the surface of the SiNW is modified with the cTnI monoclonal antibody (Mab-cTnI) upon covalent immobilization to capture cTnI antigen. The sensitivity of the device is also examined using cTnI at different concentrations with the lowest detection limit of 0.016 ng/mL. The electrocardiogram (ECG), magnetic resonance imaging (MRI), and superior vena cave (SVC) provide more information about cardiac responses in a mouse model of acute myocardial infarction (AMI). Further, magnetic resonance imaging helps to evaluate the cardiac output of an obesity induced myocardial injury mouse model. These methods play an essential role in monitoring the obesity based cardiac injury and hence, these studies were carried out. This is the first report to use the ECG, MRI, and SVC sampling methods to study the obesity based cardiac injury involving Syrian hamsters as animal models. The proposed SiNW-FET in this study shows greater sensitivity than the previously developed devices and demonstrates great potential for future applications in point-of-care (POC) diagnosis.
- Subjects :
- medicine.medical_specialty
Cardiac output
Silicon
Cardiac troponin
Biosensor device
Transistors, Electronic
Science
02 engineering and technology
030204 cardiovascular system & hematology
Article
03 medical and health sciences
Electrocardiography
0302 clinical medicine
Medical research
Electricity
Nanoscience and technology
Internal medicine
Troponin I
medicine
Electrochemistry
Animals
Humans
Myocardial infarction
cardiovascular diseases
Multidisciplinary
medicine.diagnostic_test
Mesocricetus
business.industry
Nanowires
Myocardium
Magnetic resonance imaging
021001 nanoscience & nanotechnology
medicine.disease
Magnetic Resonance Imaging
Luminescent Measurements
Models, Animal
Cardiology
cardiovascular system
Medicine
Biomarker (medicine)
Field-effect transistor
0210 nano-technology
business
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....fe286962800ad09e03fa3a71ed81209e