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Bilirubin Safeguards Cardiorenal and Metabolic Diseases: a Protective Role in Health
- Publication Year :
- 2019
-
Abstract
- PURPOSE OF REVIEW: To discuss recent advances indicating that bilirubin safeguards against cardiorenal and metabolic diseases. RECENT FINDINGS: Several investigations from human patient populations and experimental animal models have shown that bilirubin improves cardiorenal and metabolic dysfunction. The latest studies found an entirely new function of bilirubin suggesting that it acts as a hormone signaling molecule capable of activating nuclear receptors for burning fat, which may explain several of its protective actions. SUMMARY: This review highlights the current findings (within the last 3 years) regarding cardiorenal and metabolic protective effects of bilirubin and the latest mechanism(s) that may be mediating these effects.
- Subjects :
- Bilirubin
030204 cardiovascular system & hematology
Bioinformatics
Article
Antioxidants
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Metabolic Diseases
Internal Medicine
Medicine
Animals
Humans
030212 general & internal medicine
Hormone signaling
business.industry
Mechanism (biology)
Burning fat
Biliverdin reductase
Human patient
Experimental Animal Models
medicine.disease
chemistry
Cardiovascular Diseases
Hypertension
Kidney Diseases
Metabolic syndrome
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....fe2504028d1562bcbf6403a83ce6cc7b