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Preliminary Evaluation of Phosphatidylethanol and Alcohol Consumption in Patients with Liver Disease and Hypertension
- Source :
- Alcohol and Alcoholism. 44:464-467
- Publication Year :
- 2009
- Publisher :
- Oxford University Press (OUP), 2009.
-
Abstract
- Aims: The goal of this preliminary study was to evaluate the relationship between blood phosphatidylethanol (PEth) and recent drinking in patients with liver disease and hypertension. Methods: Twenty-one patients with liver disease and 21 patients with essential hypertension were recruited at an academic medical center. Alcohol consumption was estimated using validated self-report methods, and blood PEth was measured by HPLC-MS/MS at a contracted laboratory. Nonparametric comparisons were made between abstainers/light drinkers, moderate drinkers consuming between 1 and 3 drinks per day, and those drinking above this level. Regression methods were used to estimate the effects of liver disease, gender, and age on the relationship between PEth and alcohol use, and to estimate the strength of the linear relationship between PEth and drinking. Results: PEth differed significantly between the three drinking groups ( P < 0.001). The relationship between PEth and alcohol did not differ between hypertension and liver disease patients ( P = 0.696), nor by gender and age. While there was substantial variability between subjects in the PEth concentration given a similar level of reported drinking, the amount of ethanol consumed was strongly associated with the PEth concentration ( P < 0.001). Conclusion: Results support PEth measurement by HPLC-MS/MS as a promising marker of past 1- to 2-week moderate to heavy alcohol consumption in patients with and without liver disease. PEth appears useful for differentiating abstinence or light drinking from moderate to heavy consumption, but may have limited utility for differentiating moderate from heavy alcohol use.
- Subjects :
- Adult
Male
Assessment and Detection
medicine.medical_specialty
Alcohol Drinking
media_common.quotation_subject
Alcohol
Glycerophospholipids
Essential hypertension
Severity of Illness Index
Gastroenterology
Age and gender
chemistry.chemical_compound
Liver disease
Internal medicine
Prevalence
medicine
Humans
In patient
media_common
business.industry
Liver Diseases
General Medicine
Middle Aged
Abstinence
medicine.disease
Surgery
chemistry
Hypertension
Female
Phosphatidylethanol
business
Alcohol consumption
Subjects
Details
- ISSN :
- 14643502 and 07350414
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Alcohol and Alcoholism
- Accession number :
- edsair.doi.dedup.....fe2382ee3194e1219fe66aab747ba82a