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RNA CODEWORDS AND PROTEIN SYNTHESIS. II. NUCLEOTIDE SEQUENCE OF A VALINE RNA CODEWORD

Authors :
Philip Leder
Marshall W. Nirenberg
Source :
Proceedings of the National Academy of Sciences of the United States of America. 52
Publication Year :
1964

Abstract

After the poly-U experiments, the next major challenge was finding out what the remaining codewords were. In this article, the authors use a rapid method for measuring sRNA binding to ribosomes and try to resolve some problems with ambiguous and synonymous codewords. The experimental evidence suggests the binding of specific types of sRNA to ribosomes is directed by only certain corresponding trinucleotides, making sequencing efforts more feasible in the coding process.

Details

ISSN :
00278424
Volume :
52
Database :
OpenAIRE
Journal :
Proceedings of the National Academy of Sciences of the United States of America
Accession number :
edsair.doi.dedup.....fe2165fc192f6973cfe6da1499e1130c