Review: women with schizophrenia have poorer pregnancy outcomes than other women, but it is unclear whether antipsychotic medications affect their infants

(2003) Can J Psych 47, 959; Patton SW, Misiri S, Corral MR et al. . Antipsychotic medication during pregnancy and lactation in women with schizophrenia: evaluating the risk. . , Dec; . : . –65 . [OpenUrl][1] QUESTION: Does exposing infants to antipsychotic medication during pregnancy and lactation increase the risk of teratogenic, neonatal, and long-term neurobehavioural effects? Are schizophrenia symptoms altered by pregnancy and lactation, and vice versa? Systematic review. The authors searched Medline to December 2001 and the reference lists of identified articles. Studies of any design were eligible if they examined the extent to which antipsychotic medication exposure during pregnancy or lactation contributes to poor obstetrical outcomes in women with schizophrenia or poor developmental outcomes in their babies. The authors did not provide detailed inclusion or exclusion criteria, nor did they describe how data were extracted for the review. Few prospective studies were identified. There is inconsistent reporting about medication dosage and duration for infants exposed to antipsychotic medication during pregnancy and medication levels in breast milk and in infant blood and urine. Most studies include little detail about possible confounding factors, such … [1]: {openurl}?query=rft.jtitle%253DCan%2BJ%2BPsych%26rft.volume%253D47%26rft.spage%253D959%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx