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Two novel coding SNPs of SREBP1c gene are associated with body weight and average daily gain in bovine
- Source :
- Animal biotechnology. 21(3)
- Publication Year :
- 2010
-
Abstract
- It is known that the SREBP1c gene is an important gene responsible for adipogenesis and regulation of the expression of genes controlling fatty acid biosynthesis. Its expression levels increase in parallel with obesity. Therefore, the present study focused on screening the genetic variation within bovine SREBP1c gene and analyzing its effect on growth traits in 1035 individuals belonging to four Chinese cattle breeds (QC, NY, JX, CH) using PCR-SSCP, DNA sequencing, and forced PCR-RFLP methods. The results revealed two novel mutations: NC_007317: g. 10781 C > A (457aa), 10914 G > A (502aa). Association analysis with growth traits in the Nangyang breed indicated that: The SNPs in the bovine SREBP1c gene had significant effects on body weight and average daily gain at birth, 6 and 12 months old (P
- Subjects :
- Candidate gene
Genotype
Molecular Sequence Data
Bioengineering
Single-nucleotide polymorphism
Biology
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
DNA sequencing
Genetic variation
medicine
Animals
Gene
Genetic association
Genetics
Chi-Square Distribution
Base Sequence
Body Weight
Genetic Variation
DNA
medicine.disease
Obesity
Breed
Animal Science and Zoology
Cattle
Sterol Regulatory Element Binding Protein 1
Polymorphism, Restriction Fragment Length
Biotechnology
Subjects
Details
- ISSN :
- 15322378
- Volume :
- 21
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Animal biotechnology
- Accession number :
- edsair.doi.dedup.....fe05325721500fdc75045a132be78be4