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Pancreatitis After Pancreatoduodenectomy Predicts Clinically Relevant Postoperative Pancreatic Fistula
- Source :
- Journal of Gastrointestinal Surgery. 21:330-338
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- Morbidity after pancreas resection is still high with postoperative pancreatic fistulas (POPF) being the most frequent complication. However, exocrine insufficiency seems to protect from POPF. In clinical practice, patients showing increased postoperative systemic amylase concentrations appear to frequently develop POPF. We therefore retrospectively examined the occurrence of systemic amylase increase after pancreas resections and its association with the clinical course. Perioperative data from 739 consecutive pancreas resections were assessed in a prospectively maintained SPSS database. Serum and drain amylase concentrations were determined by routine clinical chemistry. POPFs were graded into A–C according to ISGPF definitions. In patients with reduced serum amylase (n = 89) on day 1 after pancreatoduodenectomy, clinically relevant POPFs were not observed. In patients with normal serum amylase concentrations, clinically relevant POPFs occurred in 9 %, while in 39 % of the patients with more than three times elevated amylase concentrations, a clinically relevant postoperative fistula was observed (p
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
030230 surgery
Gastroenterology
Pancreaticoduodenectomy
Pancreatic Fistula
Young Adult
03 medical and health sciences
Postoperative Complications
0302 clinical medicine
Risk Factors
Internal medicine
medicine
Humans
In patient
Amylase
Aged
Retrospective Studies
Aged, 80 and over
biology
business.industry
Perioperative
Middle Aged
medicine.disease
medicine.anatomical_structure
Pancreatitis
Pancreatic fistula
030220 oncology & carcinogenesis
Amylases
biology.protein
Drainage
Hyperamylasemia
Female
Surgery
Pancreas
Complication
business
Subjects
Details
- ISSN :
- 18734626 and 1091255X
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Journal of Gastrointestinal Surgery
- Accession number :
- edsair.doi.dedup.....fe02eb1265cb028d3db898dea755d851